Literature DB >> 31799904

Nonlinear Input-Output Functions of Motoneurons.

Marc D Binder1, Randall K Powers1, C J Heckman2.   

Abstract

All movements are generated by the activation of motoneurons, and hence their input-output properties define the final step in processing of all motor commands. A major challenge to understanding this transformation has been the striking nonlinear behavior of motoneurons conferred by the activation of persistent inward currents (PICs) mediated by their voltage-gated Na+ and Ca2+ channels. In this review, we focus on the contribution that these PICs make to motoneuronal discharge and how the nonlinearities they engender impede the construction of a comprehensive model of motor control.

Entities:  

Keywords:  input-output function; motoneuron; nonlinear behavior; persistent inward currents

Year:  2020        PMID： 31799904      PMCID： PMC7132324          DOI： 10.1152/physiol.00026.2019

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  75 in total

1.  Nomenclature of voltage-gated sodium channels.

Authors:  A L Goldin; R L Barchi; J H Caldwell; F Hofmann; J R Howe; J C Hunter; R G Kallen; G Mandel; M H Meisler; Y B Netter; M Noda; M M Tamkun; S G Waxman; J N Wood; W A Catterall
Journal:  Neuron       Date:  2000-11       Impact factor: 17.173

2.  Contribution of intrinsic properties and synaptic inputs to motoneuron discharge patterns: a simulation study.

Authors:  Randall K Powers; Sherif M Elbasiouny; W Zev Rymer; C J Heckman
Journal:  J Neurophysiol       Date:  2011-10-26       Impact factor: 2.714

3.  Essential role of the persistent sodium current in spike initiation during slowly rising inputs in mouse spinal neurones.

Authors:  J J Kuo; R H Lee; L Zhang; C J Heckman
Journal:  J Physiol       Date:  2006-05-25       Impact factor: 5.182

4.  Synaptic activation of plateaus in hindlimb motoneurons of decerebrate cats.

Authors:  D J Bennett; H Hultborn; B Fedirchuk; M Gorassini
Journal:  J Neurophysiol       Date:  1998-10       Impact factor: 2.714

5.  Amplification of EPSPs by axosomatic sodium channels in neocortical pyramidal neurons.

Authors:  G Stuart; B Sakmann
Journal:  Neuron       Date:  1995-11       Impact factor: 17.173

6.  A persistent negative resistance in cat lumbar motoneurons.

Authors:  P Schwindt; W E Crill
Journal:  Brain Res       Date:  1977-01-14       Impact factor: 3.252

7.  Serotonin affects movement gain control in the spinal cord.

Authors:  Kunlin Wei; Joshua I Glaser; Linna Deng; Christopher K Thompson; Ian H Stevenson; Qining Wang; Thomas George Hornby; Charles J Heckman; Konrad P Kording
Journal:  J Neurosci       Date:  2014-09-17       Impact factor: 6.167

8.  Dependence of the paired motor unit analysis on motor unit discharge characteristics in the human tibialis anterior muscle.

Authors:  Jennifer L Stephenson; Katrina S Maluf
Journal:  J Neurosci Methods       Date:  2011-04-01       Impact factor: 2.390

9.  Bistability of alpha-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan.

Authors:  J Hounsgaard; H Hultborn; B Jespersen; O Kiehn
Journal:  J Physiol       Date:  1988-11       Impact factor: 5.182

10.  Ca(2+) entry into neurons is facilitated by cooperative gating of clustered CaV1.3 channels.

Authors:  Claudia M Moreno; Rose E Dixon; Sendoa Tajada; Can Yuan; Ximena Opitz-Araya; Marc D Binder; Luis F Santana
Journal:  Elife       Date:  2016-05-17       Impact factor: 8.140
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  19 in total

1.  Evidence of two modes of spiking evoked in human firing motoneurones by Ia afferent electrical stimulation.

Authors:  Lydia P Kudina; Regina E Andreeva
Journal:  Exp Brain Res       Date:  2021-01-03       Impact factor: 1.972

2.  Estimation of self-sustained activity produced by persistent inward currents using firing rate profiles of multiple motor units in humans.

Authors:  Babak Afsharipour; Nagib Manzur; Jennifer Duchcherer; Keith F Fenrich; Christopher K Thompson; Francesco Negro; Katharina A Quinlan; David J Bennett; Monica A Gorassini
Journal:  J Neurophysiol       Date:  2020-05-27       Impact factor: 2.714

3.  Flexible neural control of motor units.

Authors:  Najja J Marshall; Joshua I Glaser; Eric M Trautmann; Elom A Amematsro; Sean M Perkins; Michael N Shadlen; L F Abbott; John P Cunningham; Mark M Churchland
Journal:  Nat Neurosci       Date:  2022-10-10       Impact factor: 28.771

4.  Electrical Properties of Adult Mammalian Motoneurons.

Authors:  Calvin C Smith; Robert M Brownstone
Journal:  Adv Neurobiol       Date:  2022

5.  The control and training of single motor units in isometric tasks are constrained by a common input signal.

Authors:  Mario Bräcklein; Deren Yusuf Barsakcioglu; Jaime Ibáñez; Jonathan Eden; Etienne Burdet; Carsten Mehring; Dario Farina
Journal:  Elife       Date:  2022-06-07       Impact factor: 8.713

Review 6.  Mechanisms and physiological implications of cooperative gating of clustered ion channels.

Authors:  Rose E Dixon; Manuel F Navedo; Marc D Binder; L Fernando Santana
Journal:  Physiol Rev       Date:  2021-12-20       Impact factor: 46.500

7.  Estimates of persistent inward currents in tibialis anterior motor units during standing ramped contraction tasks in humans.

Authors:  Obaid U Khurram; Francesco Negro; C J Heckman; Christopher K Thompson
Journal:  J Neurophysiol       Date:  2021-06-16       Impact factor: 2.974

8.  Spatial and Temporal Arrangement of Recurrent Inhibition in the Primate Upper Limb.

Authors:  Steve A Edgley; Elizabeth R Williams; Stuart N Baker
Journal:  J Neurosci       Date:  2020-12-17       Impact factor: 6.167

9.  Slowly activating outward membrane currents generate input-output sub-harmonic cross frequency coupling in neurons.

Authors:  Nirvik Sinha; C J Heckman; Yuan Yang
Journal:  J Theor Biol       Date:  2020-10-03       Impact factor: 2.691

Review 10.  GABAergic Mechanisms Can Redress the Tilted Balance between Excitation and Inhibition in Damaged Spinal Networks.

Authors:  Graciela Lujan Mazzone; Atiyeh Mohammadshirazi; Jorge Benjamin Aquino; Andrea Nistri; Giuliano Taccola
Journal:  Mol Neurobiol       Date:  2021-04-07       Impact factor: 5.590
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