PURPOSE: To demonstrate the feasibility of pseudo-continuous arterial-spin-labeled (pCASL) imaging with 3D fast-spin-echo stack-of-spirals on a compact 3T scanner (C3T), to perform trajectory correction for eddy-current-induced deviations in the spiral readout of pCASL imaging, and to assess the correction effect on perfusion-related images with high-performance gradients (80 mT/m, 700T/m/s) of the C3T. METHODS: To track eddy-current-induced artifacts with Archimedean spiral readout, the spiral readout in pCASL imaging was performed with 5 different peak gradient slew rate (Smax ) values ranging from 70 to 500 T/m/s. The trajectory for each Smax was measured using a dynamic field camera and applied in a density-compensated gridding image reconstruction in addition to the nominal trajectory. The effect of the trajectory correction was assessed with perfusion-weighted (ΔM) images and proton-density-weighted images as well as cerebral blood flow (CBF) maps, obtained from 10 healthy volunteers. RESULTS: Blurring artifact on ΔM images was mitigated by the trajectory correction. CBF values on the left and right calcarine cortices showed no significant difference after correction. Also, the signal-to-noise ratio of ΔM images improved, on average, by 7.6% after correction (P < .001). The greatest improvement of 12.1% on ΔM images was achieved with a spiral readout using Smax of 300~400 T/m/s. CONCLUSION: Eddy currents can cause spiral trajectory deviation, which leads to deformation of the CBF map even in cases of low value Smax . The trajectory correction for spiral-readout-based pCASL produces more reliable results for perfusion imaging. These results suggest that pCASL is feasible on C3T with high-performance gradients.
PURPOSE: To demonstrate the feasibility of pseudo-continuous arterial-spin-labeled (pCASL) imaging with 3D fast-spin-echo stack-of-spirals on a compact 3T scanner (C3T), to perform trajectory correction for eddy-current-induced deviations in the spiral readout of pCASL imaging, and to assess the correction effect on perfusion-related images with high-performance gradients (80 mT/m, 700T/m/s) of the C3T. METHODS: To track eddy-current-induced artifacts with Archimedean spiral readout, the spiral readout in pCASL imaging was performed with 5 different peak gradient slew rate (Smax ) values ranging from 70 to 500 T/m/s. The trajectory for each Smax was measured using a dynamic field camera and applied in a density-compensated gridding image reconstruction in addition to the nominal trajectory. The effect of the trajectory correction was assessed with perfusion-weighted (ΔM) images and proton-density-weighted images as well as cerebral blood flow (CBF) maps, obtained from 10 healthy volunteers. RESULTS:Blurring artifact on ΔM images was mitigated by the trajectory correction. CBF values on the left and right calcarine cortices showed no significant difference after correction. Also, the signal-to-noise ratio of ΔM images improved, on average, by 7.6% after correction (P < .001). The greatest improvement of 12.1% on ΔM images was achieved with a spiral readout using Smax of 300~400 T/m/s. CONCLUSION: Eddy currents can cause spiral trajectory deviation, which leads to deformation of the CBF map even in cases of low value Smax . The trajectory correction for spiral-readout-based pCASL produces more reliable results for perfusion imaging. These results suggest that pCASL is feasible on C3T with high-performance gradients.
Authors: Seung-Kyun Lee; Jean-Baptiste Mathieu; Dominic Graziani; Joseph Piel; Eric Budesheim; Eric Fiveland; Christopher J Hardy; Ek Tsoon Tan; Bruce Amm; Thomas K-F Foo; Matt A Bernstein; John Huston; Yunhong Shu; John F Schenck Journal: Magn Reson Med Date: 2015-12-02 Impact factor: 4.668
Authors: Reinoud P H Bokkers; Jochem P Bremmer; Bart N M van Berckel; Adriaan A Lammertsma; Jeroen Hendrikse; Josien P W Pluim; L Jaap Kappelle; Ronald Boellaard; Catharina J M Klijn Journal: J Cereb Blood Flow Metab Date: 2009-10-07 Impact factor: 6.200
Authors: Luis Hernandez-Garcia; Verónica Aramendía-Vidaurreta; Divya S Bolar; Weiying Dai; Maria A Fernández-Seara; Jia Guo; Ananth J Madhuranthakam; Henk Mutsaerts; Jan Petr; Qin Qin; Jonas Schollenberger; Yuriko Suzuki; Manuel Taso; David L Thomas; Matthias J P van Osch; Joseph Woods; Moss Y Zhao; Lirong Yan; Ze Wang; Li Zhao; Thomas W Okell Journal: Magn Reson Med Date: 2022-08-19 Impact factor: 3.737
Authors: Daehun Kang; Hang Joon Jo; Myung-Ho In; Uten Yarach; Nolan K Meyer; Lydia J Bardwell Speltz; Erin M Gray; Joshua D Trzasko; John Huston Iii; Matt A Bernstein; Yunhong Shu Journal: Phys Med Biol Date: 2020-11-27 Impact factor: 3.609