Daniel C Turner1, Michelle Miranda2, Jeffrey S Morris2, Christopher A Girkin3, J Crawford Downs3. 1. Department of Vision Sciences, School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama, USA. 2. The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA. 3. Department of Ophthalmology and Visual Sciences, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Abstract
Purpose: To quantify intraocular pressure (IOP) change and time course during stressful activity. Study Design: Experimental Study. Subjects: Three nonhuman primates (NHPs). Methods: Bilateral IOP and aortic blood pressure (BP) were recorded continuously, then averaged for periods of 8-30 seconds before, during, and after a common anesthetic induction procedure (cage squeeze followed by intramuscular injection). Experiments were repeated four times in each NHP. Main Outcome Measures: IOP, BP, and heart rate (HR) change during an anesthetic induction procedure. Results: IOP, mean arterial pressure (MAP), and HR increased rapidly and significantly by 27%, 38%, 34%, respectively, in anticipation of anesthetic induction (Figure; p<0.05). IOP rose ~10% within 10 seconds of hearing the technician enter the outer anteroom door, and reached its maximum within ~1 minute of first anticipating human contact. IOP fell to below baseline levels within 1 minute after anesthetic induction. Conclusions: IOP increases rapidly and significantly in response to stressful situations in the nonhuman primate.
Purpose: To quantify intraocular pressure (IOP) change and time course during stressful activity. Study Design: Experimental Study. Subjects: Three nonhuman primates (NHPs). Methods: Bilateral IOP and aortic blood pressure (BP) were recorded continuously, then averaged for periods of 8-30 seconds before, during, and after a common anesthetic induction procedure (cage squeeze followed by intramuscular injection). Experiments were repeated four times in each NHP. Main Outcome Measures: IOP, BP, and heart rate (HR) change during an anesthetic induction procedure. Results: IOP, mean arterial pressure (MAP), and HR increased rapidly and significantly by 27%, 38%, 34%, respectively, in anticipation of anesthetic induction (Figure; p<0.05). IOP rose ~10% within 10 seconds of hearing the technician enter the outer anteroom door, and reached its maximum within ~1 minute of first anticipating human contact. IOP fell to below baseline levels within 1 minute after anesthetic induction. Conclusions: IOP increases rapidly and significantly in response to stressful situations in the nonhuman primate.
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