A Hillary Steinhart1, Remo Panaccione2, Laura Targownik3, Brian Bressler4, Reena Khanna5, John K Marshall6, Waqqas Afif7, Charles N Bernstein3, Alain Bitton7, Mark Borgaonkar8, Usha Chauhan9, Brendan Halloran10, Jennifer Jones11, Erin Kennedy12, Grigorios I Leontiadis6, Edward V Loftus13, Jonathan Meddings2, Paul Moayyedi6, Sanjay Murthy14, Sophie Plamondon15, Greg Rosenfeld16, David Schwartz17, Cynthia H Seow18, Chadwick Williams19. 1. Division of Gastroenterology, Mount Sinai Hospital, Toronto, Ontario, Canada. 2. Department of Medicine, University of Calgary, Calgary, Alberta, Canada. 3. Section of Gastroenterology, University of Manitoba, Winnipeg, Manitoba, Canada. 4. Department of Medicine, Division of Gastroenterology, St Paul's Hospital, Vancouver, British Columbia, Canada. 5. Department of Medicine, University of Western Ontario, London, Ontario, Canada. 6. Division of Gastroenterology and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada. 7. Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada. 8. Faculty of Medicine, Memorial University, St John's, Newfoundland, Canada. 9. Hamilton Health Sciences, Hamilton, Ontario, Canada. 10. Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada. 11. Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. 12. Division of General Surgery, Mount Sinai Hospital, Toronto, Ontario, Canada. 13. Division of Gastroenterology & Hepatology, Mayo Clinic, Rochester, Minnesota, USA. 14. Division of Gastroenterology, University of Ottawa, Ottawa, Ontario, Canada. 15. Department of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada. 16. Division of Gastroenterology, Pacific Gastroenterology Associates, Vancouver, British Columbia, Canada. 17. Inflammatory Bowel Disease Center, Vanderbilt University, Nashville, Tennessee, USA. 18. Departments of Medicine & Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. 19. Division of Digestive Care & Endoscopy, Department of Medicine, Dartmouth General Hospital, Halifax, Nova Scotia, Canada.
Abstract
BACKGROUND: Fistulas occur in about 25% of patients with Crohn's disease (CD) and can be difficult to treat. The aim of this consensus was to provide guidance for the management of patients with perianal fistulizing CD. METHODS: A systematic literature search identified studies on the management of fistulizing CD. The quality of evidence and strength of recommendations were rated according to the Grading of Recommendation Assessment, Development and Evaluation (GRADE) approach. Statements were developed through an iterative online platform using a modified Delphi process, then finalized, and voted on by a group of specialists. RESULTS: The quality of evidence for treatment of fistulizing CD was generally of very low quality, and because of the scarcity of good randomized controlled trials (RCTs), these consensus statements generally provide conditional suggestions (5 of 7 statements). Imaging and surgical consultations were recommended in the initial assessment of patients with active fistulizing CD, particularly those with complicated disease. Antibiotic therapy is useful for initial symptom control. Antitumor necrosis factor (anti-TNF) therapy was recommended to induce symptomatic response, and continued use was suggested to achieve and maintain complete remission. The use of concomitant immunosuppressant therapies may be useful to optimize pharmacokinetic parameters when initiating anti-TNF therapy. When there has been an inadequate symptomatic response to medical management strategies, surgical therapy may provide effective fistula healing for some patients. CONCLUSIONS: Optimal management of perianal fistulizing CD requires a collaborative effort between gastroenterologists and surgeons and may include the evidence-based use of existing therapies, as well as surgical assessments and interventions when needed.
BACKGROUND: Fistulas occur in about 25% of patients with Crohn's disease (CD) and can be difficult to treat. The aim of this consensus was to provide guidance for the management of patients with perianal fistulizing CD. METHODS: A systematic literature search identified studies on the management of fistulizing CD. The quality of evidence and strength of recommendations were rated according to the Grading of Recommendation Assessment, Development and Evaluation (GRADE) approach. Statements were developed through an iterative online platform using a modified Delphi process, then finalized, and voted on by a group of specialists. RESULTS: The quality of evidence for treatment of fistulizing CD was generally of very low quality, and because of the scarcity of good randomized controlled trials (RCTs), these consensus statements generally provide conditional suggestions (5 of 7 statements). Imaging and surgical consultations were recommended in the initial assessment of patients with active fistulizing CD, particularly those with complicated disease. Antibiotic therapy is useful for initial symptom control. Antitumor necrosis factor (anti-TNF) therapy was recommended to induce symptomatic response, and continued use was suggested to achieve and maintain complete remission. The use of concomitant immunosuppressant therapies may be useful to optimize pharmacokinetic parameters when initiating anti-TNF therapy. When there has been an inadequate symptomatic response to medical management strategies, surgical therapy may provide effective fistula healing for some patients. CONCLUSIONS: Optimal management of perianal fistulizing CD requires a collaborative effort between gastroenterologists and surgeons and may include the evidence-based use of existing therapies, as well as surgical assessments and interventions when needed.
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