Literature DB >> 31798382

St. Gallen/Vienna 2019: A Brief Summary of the Consensus Discussion on the Optimal Primary Breast Cancer Treatment.

Marija Balic1, Christoph Thomssen2, Rachel Würstlein3, Michael Gnant4, Nadia Harbeck3.   

Abstract

This year, the St. Gallen Consensus Conference on early breast cancer treatment standards took place for the third time in Vienna, Austria, which is where the next conference will also take place (next date: March 17-20, 2021!). Once again, more than 3,000 participants from over 100 countries came together, and, overall, the 2019 St. Gallen/Vienna conference was a great success. After 3 days of reviews conducted by a global faculty concerning the most important evidence published in the last 2 years, the Consensus votes' challenge was to define the impact on routine everyday practice. This year, the conference's main theme was the optimization of early breast cancer therapies by assessment of the magnitude of benefit, aiming at further refinement when compared to de-escalation and escalation, which were mainly the topic of the 2017 conference. Patient empowerment and the importance of shared decision-making were particularly emphasized. The traditional panel votes were moderated by Eric Winer from Harvard, and for the most part, they managed to clarify most of the critical questions. This brief report by Editors of Breast Care summarizes the results of the 2019 international panel votes with respect to locoregional and systemic treatment as a quick news update for our readers, but it expressly does not intend to replace the official St. Gallen Consensus publication that will follow shortly in Annals of Oncology.
Copyright © 2019 by S. Karger AG, Basel.

Entities:  

Keywords:  Adjuvant treatment; Axillary dissection; Bisphosphonates; Breast surgery; Chemotherapy; Denosumab; Early breast cancer; Endocrine therapy; Neoadjuvant systemic therapy; Radiotherapy; Sentinel node; Targeted therapy

Year:  2019        PMID: 31798382      PMCID: PMC6886108          DOI: 10.1159/000499931

Source DB:  PubMed          Journal:  Breast Care (Basel)        ISSN: 1661-3791            Impact factor:   2.860


  13 in total

Review 1.  Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: A Cancer Care Ontario and American Society of Clinical Oncology Clinical Practice Guideline.

Authors:  Sukhbinder Dhesy-Thind; Glenn G Fletcher; Phillip S Blanchette; Mark J Clemons; Melissa S Dillmon; Elizabeth S Frank; Sonal Gandhi; Rasna Gupta; Mihaela Mates; Beverly Moy; Ted Vandenberg; Catherine H Van Poznak
Journal:  J Clin Oncol       Date:  2017-03-06       Impact factor: 44.544

2.  Adjuvant denosumab in breast cancer (ABCSG-18): a multicentre, randomised, double-blind, placebo-controlled trial.

Authors:  Michael Gnant; Georg Pfeiler; Peter C Dubsky; Michael Hubalek; Richard Greil; Raimund Jakesz; Viktor Wette; Marija Balic; Ferdinand Haslbauer; Elisabeth Melbinger; Vesna Bjelic-Radisic; Silvia Artner-Matuschek; Florian Fitzal; Christian Marth; Paul Sevelda; Brigitte Mlineritsch; Günther G Steger; Diether Manfreda; Ruth Exner; Daniel Egle; Jonas Bergh; Franz Kainberger; Susan Talbot; Douglas Warner; Christian Fesl; Christian F Singer
Journal:  Lancet       Date:  2015-05-31       Impact factor: 79.321

3.  Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial.

Authors:  Miguel Martin; Frankie A Holmes; Bent Ejlertsen; Suzette Delaloge; Beverly Moy; Hiroji Iwata; Gunter von Minckwitz; Stephen K L Chia; Janine Mansi; Carlos H Barrios; Michael Gnant; Zorica Tomašević; Neelima Denduluri; Robert Šeparović; Erhan Gokmen; Anna Bashford; Manuel Ruiz Borrego; Sung-Bae Kim; Erik Hugger Jakobsen; Audrone Ciceniene; Kenichi Inoue; Friedrich Overkamp; Joan B Heijns; Anne C Armstrong; John S Link; Anil Abraham Joy; Richard Bryce; Alvin Wong; Susan Moran; Bin Yao; Feng Xu; Alan Auerbach; Marc Buyse; Arlene Chan
Journal:  Lancet Oncol       Date:  2017-11-13       Impact factor: 41.316

4.  70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer.

Authors:  Fatima Cardoso; Laura J van't Veer; Jan Bogaerts; Leen Slaets; Giuseppe Viale; Suzette Delaloge; Jean-Yves Pierga; Etienne Brain; Sylvain Causeret; Mauro DeLorenzi; Annuska M Glas; Vassilis Golfinopoulos; Theodora Goulioti; Susan Knox; Erika Matos; Bart Meulemans; Peter A Neijenhuis; Ulrike Nitz; Rodolfo Passalacqua; Peter Ravdin; Isabel T Rubio; Mahasti Saghatchian; Tineke J Smilde; Christos Sotiriou; Lisette Stork; Carolyn Straehle; Geraldine Thomas; Alastair M Thompson; Jacobus M van der Hoeven; Peter Vuylsteke; René Bernards; Konstantinos Tryfonidis; Emiel Rutgers; Martine Piccart
Journal:  N Engl J Med       Date:  2016-08-25       Impact factor: 91.245

5.  Adjuvant Pertuzumab and Trastuzumab in Early HER2-Positive Breast Cancer.

Authors:  Gunter von Minckwitz; Marion Procter; Evandro de Azambuja; Dimitrios Zardavas; Mark Benyunes; Giuseppe Viale; Thomas Suter; Amal Arahmani; Nathalie Rouchet; Emma Clark; Adam Knott; Istvan Lang; Christelle Levy; Denise A Yardley; Jose Bines; Richard D Gelber; Martine Piccart; Jose Baselga
Journal:  N Engl J Med       Date:  2017-06-05       Impact factor: 91.245

Review 6.  St. Gallen/Vienna 2017: A Brief Summary of the Consensus Discussion about Escalation and De-Escalation of Primary Breast Cancer Treatment.

Authors:  Michael Gnant; Nadia Harbeck; Christoph Thomssen
Journal:  Breast Care (Basel)       Date:  2017-04-26       Impact factor: 2.860

7.  Adjuvant ovarian suppression in premenopausal breast cancer.

Authors:  Prudence A Francis; Meredith M Regan; Gini F Fleming; István Láng; Eva Ciruelos; Meritxell Bellet; Hervé R Bonnefoi; Miguel A Climent; Gian Antonio Da Prada; Harold J Burstein; Silvana Martino; Nancy E Davidson; Charles E Geyer; Barbara A Walley; Robert Coleman; Pierre Kerbrat; Stefan Buchholz; James N Ingle; Eric P Winer; Manuela Rabaglio-Poretti; Rudolf Maibach; Barbara Ruepp; Anita Giobbie-Hurder; Karen N Price; Marco Colleoni; Giuseppe Viale; Alan S Coates; Aron Goldhirsch; Richard D Gelber
Journal:  N Engl J Med       Date:  2014-12-11       Impact factor: 91.245

8.  Adjuvant exemestane with ovarian suppression in premenopausal breast cancer.

Authors:  Olivia Pagani; Meredith M Regan; Barbara A Walley; Gini F Fleming; Marco Colleoni; István Láng; Henry L Gomez; Carlo Tondini; Harold J Burstein; Edith A Perez; Eva Ciruelos; Vered Stearns; Hervé R Bonnefoi; Silvana Martino; Charles E Geyer; Graziella Pinotti; Fabio Puglisi; Diana Crivellari; Thomas Ruhstaller; Eric P Winer; Manuela Rabaglio-Poretti; Rudolf Maibach; Barbara Ruepp; Anita Giobbie-Hurder; Karen N Price; Jürg Bernhard; Weixiu Luo; Karin Ribi; Giuseppe Viale; Alan S Coates; Richard D Gelber; Aron Goldhirsch; Prudence A Francis
Journal:  N Engl J Med       Date:  2014-06-01       Impact factor: 91.245

9.  Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer.

Authors:  Joseph A Sparano; Robert J Gray; Della F Makower; Kathleen I Pritchard; Kathy S Albain; Daniel F Hayes; Charles E Geyer; Elizabeth C Dees; Matthew P Goetz; John A Olson; Tracy Lively; Sunil S Badve; Thomas J Saphner; Lynne I Wagner; Timothy J Whelan; Matthew J Ellis; Soonmyung Paik; William C Wood; Peter M Ravdin; Maccon M Keane; Henry L Gomez Moreno; Pavan S Reddy; Timothy F Goggins; Ingrid A Mayer; Adam M Brufsky; Deborah L Toppmeyer; Virginia G Kaklamani; Jeffrey L Berenberg; Jeffrey Abrams; George W Sledge
Journal:  N Engl J Med       Date:  2018-06-03       Impact factor: 91.245

10.  Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer.

Authors:  Gunter von Minckwitz; Chiun-Sheng Huang; Max S Mano; Sibylle Loibl; Eleftherios P Mamounas; Michael Untch; Norman Wolmark; Priya Rastogi; Andreas Schneeweiss; Andres Redondo; Hans H Fischer; William Jacot; Alison K Conlin; Claudia Arce-Salinas; Irene L Wapnir; Christian Jackisch; Michael P DiGiovanna; Peter A Fasching; John P Crown; Pia Wülfing; Zhimin Shao; Elena Rota Caremoli; Haiyan Wu; Lisa H Lam; David Tesarowski; Melanie Smitt; Hannah Douthwaite; Stina M Singel; Charles E Geyer
Journal:  N Engl J Med       Date:  2018-12-05       Impact factor: 176.079

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  39 in total

1.  The effect of omitting axillary dissection and the impact of radiotherapy on patients with breast cancer sentinel node macrometastases: a cohort study following the ACOSOG Z0011 and AMAROS trials.

Authors:  Carlos Ortega Expósito; Catalina Falo; Sonia Pernas; Samuel Pérez Carton; Miguel Gil Gil; Raul Ortega; Héctor Pérez Montero; Agostina Stradella; Evelyn Martinez; Maria Laplana; Sira Salinas; Ana Luzardo; Teresa Soler; Maria Eulalia Fernández Montoli; Juan Azcarate; Anna Guma; Anna Petit; Ana Benitez; Maite Bajen; Jose G Reyes Junca; Miriam Campos; Raquel Ruiz; Jordi Ponce; Maria J Pla; Amparo García Tejedor
Journal:  Breast Cancer Res Treat       Date:  2021-06-04       Impact factor: 4.872

2.  Real-World Outcomes Among Older Mexican Women with Breast Cancer Treated with Neoadjuvant Chemotherapy.

Authors:  Paula Cabrera-Galeana; Enrique Soto-Perez-de-Celis; Nancy Reynoso-Noveron; Cynthia Villarreal-Garza; Fernando Lara-Medina; Alberto Alvarado-Miranda; José Rodrigo Espinosa-Fernandez; Nereida Esparza-Arias; Alejandro Mohar; Juan Enrique Bargallo-Rocha
Journal:  Oncologist       Date:  2020-04-28

3.  Bisphosphonate Choice as Adjuvant Therapy for Breast Cancer: Does it Matter?

Authors:  Adam Brufsky; Aju Mathew
Journal:  J Natl Cancer Inst       Date:  2020-07-01       Impact factor: 13.506

4.  High FUT3 expression is a marker of lower overall survival of breast cancer patients.

Authors:  Jessica Catarine Frutuoso do Nascimento; Eduardo Isidoro Carneiro Beltrão; Cíntia Renata Costa Rocha
Journal:  Glycoconj J       Date:  2020-02-15       Impact factor: 2.916

5.  Prognostic and predictive parameters in breast pathology: a pathologist's primer.

Authors:  Kimberly H Allison
Journal:  Mod Pathol       Date:  2020-11-05       Impact factor: 7.842

6.  Adjuvant Chemotherapy for Patients with Breast Cancer Based on Clinical and Evolving Oncotype DX Criteria.

Authors:  Jamal Zekri; Meteb Al-Foheidi; Maaz Alata; Reem Zabani; Ayman Rasmy
Journal:  Breast Care (Basel)       Date:  2020-03-10       Impact factor: 2.860

7.  Effectiveness of a 6-Month 22.5-mg Leuprolide Acetate Depot Formulation With Tamoxifen for Postoperative Premenopausal Estrogen Suppression in Hormone Receptor-Positive Breast Cancer.

Authors:  Zhen-Yu Wu; Young-Jin Lee; Heejeong Kim; Jongwon Lee; Il Yong Chung; Jisun Kim; Saebyeol Lee; Byung-Ho Son; Sung-Bae Kim; Jae Ho Jeong; Gyungyub Gong; Sei-Hyun Ahn; BeomSeok Ko
Journal:  Front Oncol       Date:  2021-04-28       Impact factor: 6.244

Review 8.  Genomic Signatures in Luminal Breast Cancer.

Authors:  Julian Puppe; Tabea Seifert; Christian Eichler; Henryk Pilch; Peter Mallmann; Wolfram Malter
Journal:  Breast Care (Basel)       Date:  2020-07-21       Impact factor: 2.860

9.  PI3K activation promotes resistance to eribulin in HER2-negative breast cancer.

Authors:  Javier Cortés; Violeta Serra; Albert Gris-Oliver; Yasir H Ibrahim; Martín A Rivas; Celina García-García; Mònica Sánchez-Guixé; Fiorella Ruiz-Pace; Cristina Viaplana; José M Pérez-García; Antonio Llombart-Cussac; Judit Grueso; Mireia Parés; Marta Guzmán; Olga Rodríguez; Pilar Anton; Patricia Cozar; Maria Teresa Calvo; Alejandra Bruna; Joaquín Arribas; Carlos Caldas; Rodrigo Dienstmann; Paolo Nuciforo; Mafalda Oliveira
Journal:  Br J Cancer       Date:  2021-03-15       Impact factor: 7.640

10.  Breast-Gynaecological & Immuno-Oncology International Cancer Conference (BGICC) Consensus and Recommendations for the Management of Triple-Negative Breast Cancer.

Authors:  Hesham Elghazaly; Hope S Rugo; Hamdy A Azim; Sandra M Swain; Banu Arun; Matti Aapro; Edith A Perez; Benjamin O Anderson; Frederique Penault-Llorca; Pierfranco Conte; Nagi S El Saghir; Cheng-Har Yip; Marwan Ghosn; Philip Poortmans; Mohamed A Shehata; Armando E Giuliano; Jessica W T Leung; Valentina Guarneri; Joseph Gligorov; Bahadir M Gulluoglu; Hany Abdel Aziz; Mona Frolova; Mohamed Sabry; Charles M Balch; Roberto Orecchia; Heba M El-Zawahry; Sana Al-Sukhun; Khaled Abdel Karim; Alaa Kandil; Ruslan M Paltuev; Meteb Foheidi; Mohamed El-Shinawi; Manal ElMahdy; Omalkhair Abulkhair; Wentao Yang; Adel T Aref; Joaira Bakkach; Nermean Bahie Eldin; Hagar Elghazawy
Journal:  Cancers (Basel)       Date:  2021-05-08       Impact factor: 6.639

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