Tejashree Mantri1, Sanjay G Thete2, Vijayalaxmi Male3, Renu Yadav2, Ishita Grover4, Girija R Adsure5, Dinraj Kulkarni6. 1. Department of Oral Medicine and Radiology, Maharashtra Institute of Dental Sciences and Research, Latur, Maharashtra, India, Phone: +91 8169932296, e-mail: mantritejashree@gmail.com. 2. Department of Oral Pathology and Microbiology, Rural Dental College, Pravara Institute of Medical Sciences (Deemed University) Loni, Maharashtra, India. 3. Department of Oral Medicine and Radiology, Maharashtra Institute of Dental Sciences and Research, Latur, Maharashtra, India. 4. Department of Prosthodontics and Implantology, M.A. Rangoonwala College of Dental Sciences and Research Center, Pune, Maharashtra, India. 5. Department of Dentofacial Orthopedics and Orthodontics, M.A. Rangoonwala College of Dental Sciences and Research Institute, Pune, Maharashtra, India. 6. Department of Oral and Maxillofacial Pathology, M.A. Rangoonwala College of Dental Sciences and Research Institute, Pune, Maharashtra, India.
Abstract
AIM: To evaluate the salivary lactate dehydrogenase (LDH) levels in clinico-pathologically confirmed oral submucous fibrosis (OSMF), oral cancer and clinically diagnosed tobacco pouch keratosis patients. MATERIALS AND METHODS: A prospective, comparative study was carried out in a tertiary healthcare centre located in Loni from October 2013 to January 2014. A total of 120 patients were separated into 4 groups depending upon the clinical diagnosis as follows. Group I: healthy control (with no addictions and diseases). Group II: oral cancer. Group III: oral submucous fibrosis. Group IV: habitual tobacco chewers (tobacco addiction without any disease). Substantiation was done using biopsy. The samples were inspected for salivary LDH levels by the technique in line with the recommendations of the International Federation of Clinical Chemistry with the help of Erba Chem semi auto analyser. RESULTS: The mean salivary LDH levels in the control, oral cancer OSMF and habitual tobacco chewer group were 86.12 ± 7.05 IU/L, 592.09 ± 28.57 IU/L, 350.43 ± 5.90 IU/L and 125.19 ± 13.42 IU/L, respectively. Out of 4 groups, LDH activity was increased in saliva of patients with tobacco pouch keratosis, OSMF, and oral cancer consistently. Notable difference was found in the mean salivary levels of the above groups. Results were subjected to appropriate statistical analysis: one-way ANOVA, Student's unpaired t test for group-wise comparison followed by post hoc Tukey's test. CONCLUSION: We observed congruous higher levels of salivary LDH in oral precancer and cancer, and hence it could be a future marker.
AIM: To evaluate the salivary lactate dehydrogenase (LDH) levels in clinico-pathologically confirmed oral submucous fibrosis (OSMF), oral cancer and clinically diagnosed tobacco pouch keratosis patients. MATERIALS AND METHODS: A prospective, comparative study was carried out in a tertiary healthcare centre located in Loni from October 2013 to January 2014. A total of 120 patients were separated into 4 groups depending upon the clinical diagnosis as follows. Group I: healthy control (with no addictions and diseases). Group II: oral cancer. Group III: oral submucous fibrosis. Group IV: habitual tobacco chewers (tobacco addiction without any disease). Substantiation was done using biopsy. The samples were inspected for salivary LDH levels by the technique in line with the recommendations of the International Federation of Clinical Chemistry with the help of Erba Chem semi auto analyser. RESULTS: The mean salivary LDH levels in the control, oral cancer OSMF and habitual tobacco chewer group were 86.12 ± 7.05 IU/L, 592.09 ± 28.57 IU/L, 350.43 ± 5.90 IU/L and 125.19 ± 13.42 IU/L, respectively. Out of 4 groups, LDH activity was increased in saliva of patients with tobacco pouch keratosis, OSMF, and oral cancer consistently. Notable difference was found in the mean salivary levels of the above groups. Results were subjected to appropriate statistical analysis: one-way ANOVA, Student's unpaired t test for group-wise comparison followed by post hoc Tukey's test. CONCLUSION: We observed congruous higher levels of salivary LDH in oral precancer and cancer, and hence it could be a future marker.
Authors: Anitha Krishnan Pandarathodiyil; Anand Ramanathan; Ranjana Garg; Jennifer Geraldine Doss; Fazliny Binti Abd Rahman; Wan Maria Nabillah Ghani; Saman Warnakulasuriya Journal: Asian Pac J Cancer Prev Date: 2021-10-01