| Literature DB >> 31797761 |
Jiayang Xie1, Ruirui Liang1, Yajiang Wang1, Junyi Huang1, Xin Cao2, Bing Niu1,2.
Abstract
Alzheimer's disease (AD) is a chronic neurodegenerative disease that 4 widespread in the elderly. The etiology of AD is complicated, and its pathogenesis is still unclear. Although there are many researches on anti-AD drugs, they are limited to reverse relief symptoms and cannot treat diseases. Therefore, the development of high-efficiency anti-AD drugs with no side effects has become an urgent need. Based on the published literature, this paper summarizes the main targets of AD and their drugs, and focuses on the research and development progress of these drugs in recent years. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Entities:
Keywords: Acetylcholinesterase (AChE); Amyloid beta (Aβ); Amyloid-beta binding alcohol dehydrogenase (ABAD); B-site APP cleaving enzyme 1 (BACE1); Butyrylcholinesterasezzm321990(BChE); Cyclin-dependent kinase-5 (CDK-5); Glycogen synthasezzm321990kinase-3β (GSK-3β); Monoamine oxidase (MAO); Tau protein.
Mesh：
Year: 2020 PMID： 31797761 DOI： 10.2174/1568026619666191203113745
Source DB: PubMed Journal: Curr Top Med Chem ISSN： 1568-0266 Impact factor: 3.295