Veronica Cimolin1, Nicola Cau2, Manuela Galli3, Massimiliano Pau4, Cinzia Parisio2, Antonella Saezza5, Graziano Grugni5, Paolo Capodaglio2. 1. Department of Electronics, Information and Bioengineering, Politecnico di Milano, p.zza Leonardo Da Vinci 32, 20133, Milan, Italy. veronica.cimolin@polimi.it. 2. Orthopaedic Rehabilitation Unit and Clinical Lab for Gait Analysis and Posture, Ospedale San Giuseppe, Istituto Auxologico Italiano, IRCCS, Piancavallo, Verbania, Italy. 3. Department of Electronics, Information and Bioengineering, Politecnico di Milano, p.zza Leonardo Da Vinci 32, 20133, Milan, Italy. 4. Department of Mechanical, Chemical and Materials Engineering, University of Cagliari, Cagliari, Italy. 5. Unit of Auxology, Ospedale San Giuseppe, Istituto Auxologico Italiano, IRCCS, Piancavallo, VB, Italy.
Abstract
PURPOSE: Individuals with Prader-Willi syndrome (PWS) exhibit reduced lean body mass and increased fat-lean mass ratio when compared with individuals of normal weight and obese ones. Thus, research on the association of functional limitations during gait and body composition may be of great importance from a rehabilitative viewpoint. In particular, the aim of this study was to compare the gait profile of persons with PWS to that of unaffected individuals and to see if a relationship exists between gait profile and body composition in individuals with PWS. METHODS: Eighteen individuals with PWS and 20 unaffected individuals (Healthy Group: HG) were assessed. Their gait pattern was quantified with 3D-Gait Analysis (3D-GA). Overall body weight, lean and fat masses were measured by dual-energy X-ray absorptiometry. RESULTS: Individuals with PWS were found to be characterized by a significantly different (p < 0.05) gait pattern with respect to healthy controls in terms of both kinematic and kinetic parameters. No correlations were found between kinematic parameters and overall mass and lean/fat mass, while some parameters associated with ground reaction force were found to be significantly correlated with overall mass, lean mass and fat mass. Significant regression models were obtained, including impact and propulsive force and loading rate. CONCLUSION: Our data suggest that in individuals with PWS, gait is influenced by the overall and lean body mass. Thus, therapeutic strategies should target both weight reduction and lean mass increase to optimize gait, minimize articular stress, and reduce the risk of repetitive strain on the lower limbs. LEVEL OF EVIDENCE: Level III: Case-control analytic study.
PURPOSE: Individuals with Prader-Willi syndrome (PWS) exhibit reduced lean body mass and increased fat-lean mass ratio when compared with individuals of normal weight and obese ones. Thus, research on the association of functional limitations during gait and body composition may be of great importance from a rehabilitative viewpoint. In particular, the aim of this study was to compare the gait profile of persons with PWS to that of unaffected individuals and to see if a relationship exists between gait profile and body composition in individuals with PWS. METHODS: Eighteen individuals with PWS and 20 unaffected individuals (Healthy Group: HG) were assessed. Their gait pattern was quantified with 3D-Gait Analysis (3D-GA). Overall body weight, lean and fat masses were measured by dual-energy X-ray absorptiometry. RESULTS: Individuals with PWS were found to be characterized by a significantly different (p < 0.05) gait pattern with respect to healthy controls in terms of both kinematic and kinetic parameters. No correlations were found between kinematic parameters and overall mass and lean/fat mass, while some parameters associated with ground reaction force were found to be significantly correlated with overall mass, lean mass and fat mass. Significant regression models were obtained, including impact and propulsive force and loading rate. CONCLUSION: Our data suggest that in individuals with PWS, gait is influenced by the overall and lean body mass. Thus, therapeutic strategies should target both weight reduction and lean mass increase to optimize gait, minimize articular stress, and reduce the risk of repetitive strain on the lower limbs. LEVEL OF EVIDENCE: Level III: Case-control analytic study.
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Authors: Linda Reus; Sigrid Pillen; Ben J Pelzer; Janielle A A E M van Alfen-van der Velden; Anita C S Hokken-Koelega; Machiel Zwarts; Barto J Otten; Maria W G Nijhuis-van der Sanden Journal: Pediatrics Date: 2014-12 Impact factor: 7.124
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