Valentina Tardivo1,2, Federica Penner3, Diego Garbossa3, Giuseppe Di Perna3, Paolo Pacca3, Luca Salvati3, Roberto Altieri4, Silvia Grottoli5, Francesco Zenga3. 1. Department of Surgical Sciences, University of Torino, 10126, Turin, Italy. tardivo.valentina@gmail.com. 2. Neurosurgery Unit, Ente Ospedaliero Galliera, Genoa, Italy. tardivo.valentina@gmail.com. 3. Department of Neuroscience "Rita Levi Montalcini", Neurosurgery Unit, University of Torino, 10126, Turin, Italy. 4. Department of Anatomy, Biology and Genetics, Legal Medicine, Neuroscience, Diagnostic Pathology, Hygiene and Public Health (DANA) "Gian Filippo Ingrassia", Univeristy of Catania, Catania, Italy. 5. Division of Endocrinology, Diabetes and Metabolism, Department of Medical Science, University of Torino, Turin, Italy.
Abstract
PURPOSE: Along with increased life expectancy and improvements in the diagnostic tools and techniques, the number of elderly patients with symptomatic pituitary tumors being evaluated for surgery is increasing. To date, contrasting results of the safety and effectiveness of transsphenoidal surgery in patients over 65 years old were published in the medical literature. An investigation concerning the extension of resection, post operative complications and, recovery rate from endocrinological and visual symptoms in elderly patients who underwent transsphenoidal surgery for pituitary adenoma was conducted. METHODS: A retrospective review, which included a series of 81 patients 65 years old or older who underwent endoscopic endonasal surgery for pituitary adenomas was analyzed. Pre operative and post operative data were collected and patients were then compared among four age groups: 65-69 years old, 70-74 years old, 75-79 years old and 80 years and over. The results were then compared with the findings from the medical literature review. RESULTS: The statistical analysis failed to highlight any difference in terms of clinical presentation or complications among the four age groups, however there seems to be a slightly higher risk of post operative hypopituitarism in patients over 74 years old. CONCLUSION: The results of the study seem to confirm that transsphenoidal surgery for PA is safe and effective among patients that are 65 and over. Moreover, a partial resection is preferred over a gross total one in order to reduce the surgical risk.
PURPOSE: Along with increased life expectancy and improvements in the diagnostic tools and techniques, the number of elderly patients with symptomatic pituitary tumors being evaluated for surgery is increasing. To date, contrasting results of the safety and effectiveness of transsphenoidal surgery in patients over 65 years old were published in the medical literature. An investigation concerning the extension of resection, post operative complications and, recovery rate from endocrinological and visual symptoms in elderly patients who underwent transsphenoidal surgery for pituitary adenoma was conducted. METHODS: A retrospective review, which included a series of 81 patients 65 years old or older who underwent endoscopic endonasal surgery for pituitary adenomas was analyzed. Pre operative and post operative data were collected and patients were then compared among four age groups: 65-69 years old, 70-74 years old, 75-79 years old and 80 years and over. The results were then compared with the findings from the medical literature review. RESULTS: The statistical analysis failed to highlight any difference in terms of clinical presentation or complications among the four age groups, however there seems to be a slightly higher risk of post operative hypopituitarism in patients over 74 years old. CONCLUSION: The results of the study seem to confirm that transsphenoidal surgery for PA is safe and effective among patients that are 65 and over. Moreover, a partial resection is preferred over a gross total one in order to reduce the surgical risk.
Entities:
Keywords:
Elderly; Endoscopic surgery; Pituitary adenoma; Transsphenoidal surgery
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