Literature DB >> 3179713

Morphine alters preproenkephalin gene expression.

G R Uhl1, J P Ryan, J P Schwartz.   

Abstract

Rats made tolerant/dependent to morphine by s.c. implantation of drug pellets displayed a significant decrease in striatal preproenkephalin mRNA that persisted during the period of withdrawal. Levels of Met-enkephalin were normal at the end of treatment, but reduced after withdrawal. The direction and time-course of these alterations are consistent with roles for altered neuronal gene expression in the phenomena of opiate tolerance and dependence.

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Year:  1988        PMID： 3179713     DOI： 10.1016/0006-8993(88)90658-0

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  20 in total

1.  Pleiotropic opioid regulation of spinal endomorphin 2 release and its adaptations to opioid withdrawal are sexually dimorphic.

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2.  Effects of prolonged treatment with the opiate tramadol on prodynorphin gene expression in rat CNS.

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Review 3.  Neuropeptide gene expression and neural activity: assessing a working hypothesis in nucleus caudalis and dorsal horn neurons expressing preproenkephalin and preprodynorphin.

Authors:  G R Uhl; T Nishimori
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Review 4.  The molecular biology of addictive drugs.

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Journal:  Mol Neurobiol       Date:  1991       Impact factor: 5.590

Review 5.  Factors regulating the activity of striatal neurons: new perspectives from in situ hybridization histochemistry.

Authors:  B Morris
Journal:  Cell Mol Neurobiol       Date:  1990-03       Impact factor: 5.046

Review 6.  Pharmacokinetic and pharmacodynamic principles of illicit drug use and treatment of illicit drug users.

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Journal:  Clin Pharmacokinet       Date:  1997-11       Impact factor: 6.447

Review 7.  Reward processing by the opioid system in the brain.

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Journal:  Physiol Rev       Date:  2009-10       Impact factor: 37.312

8.  Transgene-mediated enkephalin expression attenuates signs of naloxone-precipitated morphine withdrawal in rats with neuropathic pain.

Authors:  Shuanglin Hao; Jian Hu; David J Fink
Journal:  Behav Brain Res       Date:  2008-08-12       Impact factor: 3.332

9.  Hypothalamic injection of non-opioid peptides increases gene expression of the opioid enkephalin in hypothalamic and mesolimbic nuclei: Possible mechanism underlying their behavioral effects.

Authors:  Olga Karatayev; Jessica R Barson; Guo-Qing Chang; Sarah F Leibowitz
Journal:  Peptides       Date:  2009-09-24       Impact factor: 3.750

10.  Differential time course of effects of kappa-opioid agonist treatment on dynorphin A levels and kappa-opioid receptor density.

Authors:  Claudio D'Addario; Manuela Di Benedetto; Sari Izenwasser; Sanzio Candeletti; Patrizia Romualdi
Journal:  J Mol Neurosci       Date:  2004       Impact factor: 3.444
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