Nanette Santoro1, Samar R El Khoudary2, Alexis Nasr2, Ellen B Gold3, Gail Greendale4, Dan McConnell5, Genevieve Neal-Perry6, Jelena Pavlovic7, Carol Derby8, Sybil Crawford9. 1. Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO. 2. Epidemiology Data Center, University of Pittsburgh, Pittsburgh, PA. 3. Department of Public Health Sciences, University of California Davis, Davis, CA. 4. Department of Medicine, University of California at Los Angeles/David Geffen School of Medicine, Los Angeles, CA. 5. Core Ligand Assay Satellite Services (CLASS) Laboratories, University of Michigan, Ann Arbor, MI. 6. Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA. 7. Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, NY. 8. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY. 9. Department of Medicine, University of Massachusetts Medical Center, Worcester, MA.
Abstract
OBJECTIVE: To further characterize the endocrinology of the menopause transition, we sought to determine: whether relationships between urine and serum hormones are maintained as women enter their sixth decade; whether a single luteal phase serum progesterone (P) is reflective of integrated-luteal urinary pregnanediol glucuronide (uPdg); and whether serum P, like luteal uPdg, declines as women approach their final menses (FMP). METHODS: The Study of Women's Health Across the Nation (SWAN) Daily Hormone Study's (DHS) is a community-based observational study. A subset of participants underwent a timed, luteal blood draw planned for cycle days 16 to 24 during the same month of DHS collection. Serum-luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol and P, and urine LH, FSH, estrone conjugates (E1c), and daily and integrated luteal uPdg were measured in 268 samples from 170 women. Serum/urine hormone associations were determined using Pearson's correlation and linear regression, adjusted for concurrent age, body mass index, smoking status, and race/ethnicity. RESULTS: Pearson's r ranged from 0.573 (for LH) to 0.843 (for FSH) for serum/urine correlations. Integrated luteal uPdg weakly correlated with serum P (Pearson's r = 0.26, P = 0.004) and explained 7% of the variability in serum P in adjusted linear regression (total R 0.09, P = 0.002). Serum P demonstrated a marginally significant decline with approaching FMP in adjusted analysis (P = 0.04). CONCLUSIONS: Urine and serum hormones maintain a close relationship in women into their sixth decade of life. Serum luteal P was weakly reflective of luteal Pdg excretion.
OBJECTIVE: To further characterize the endocrinology of the menopause transition, we sought to determine: whether relationships between urine and serum hormones are maintained as women enter their sixth decade; whether a single luteal phase serum progesterone (P) is reflective of integrated-luteal urinary pregnanediol glucuronide (uPdg); and whether serum P, like luteal uPdg, declines as women approach their final menses (FMP). METHODS: The Study of Women's Health Across the Nation (SWAN) Daily Hormone Study's (DHS) is a community-based observational study. A subset of participants underwent a timed, luteal blood draw planned for cycle days 16 to 24 during the same month of DHS collection. Serum-luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol and P, and urine LH, FSH, estrone conjugates (E1c), and daily and integrated luteal uPdg were measured in 268 samples from 170 women. Serum/urine hormone associations were determined using Pearson's correlation and linear regression, adjusted for concurrent age, body mass index, smoking status, and race/ethnicity. RESULTS:Pearson's r ranged from 0.573 (for LH) to 0.843 (for FSH) for serum/urine correlations. Integrated luteal uPdg weakly correlated with serum P (Pearson's r = 0.26, P = 0.004) and explained 7% of the variability in serum P in adjusted linear regression (total R 0.09, P = 0.002). Serum P demonstrated a marginally significant decline with approaching FMP in adjusted analysis (P = 0.04). CONCLUSIONS: Urine and serum hormones maintain a close relationship in women into their sixth decade of life. Serum luteal P was weakly reflective of luteal Pdg excretion.
Authors: A Kassam; J W Overstreet; C Snow-Harter; M J De Souza; E B Gold; B L Lasley Journal: Environ Health Perspect Date: 1996-04 Impact factor: 9.031
Authors: Bethany Sander; Amira Muftah; Laurie Sykes Tottenham; Julia A Grummisch; Jennifer L Gordon Journal: Biol Sex Differ Date: 2021-07-30 Impact factor: 5.027