Maurizio Filippini1, Daniela Luvero2, Stefano Salvatore3, Annalisa Pieralli4, Roberto Montera2, Francesco Plotti2, Massimo Candiani3, Roberto Angioli2. 1. Department of Obstetrics and Gynecology, Hospital State of Republic of San Marino, San Marino, Republic of San Marino. 2. Department of Obstetrics and Gynecology, Campus Bio-Medico University, Rome, Italy. 3. Department of Obstetrics and Gynecology, IRCCS San Raffaele Hospital, Milan, Italy. 4. Department of Obstetrics and Gynecology, Department of Woman and Child Health, Careggi University Hospital, Florence, Italy.
Abstract
OBJECTIVE: Genitourinary syndrome of menopause (GSM), especially vulvovaginal atrophy (VVA), is one of the most common conditions among women in either natural (4%-47%) or medically induced (23.4%-61.5%) menopause. The aims of this study are to assess the efficacy and effectiveness of CO2 laser in postmenopausal women with clinical signs and symptoms of GSM, in particular VVA, and to evaluate both possible early and late side effects related to this kind of treatment. METHODS: This retrospective, multicenter study was conducted after collecting data from a pre-existing database. We performed three to four CO2 laser treatments on all the women enrolled in this protocol. We used a fractional CO2 laser system (SmartXide VLR, Deka m.e.l.a., Florence, Italy) with a VulvoVaginal Laser Reshaping (VLR) scanning system and appropriate handpieces for the vaginal area. All women before and after the treatment were assessed. The pre- and post-treatment averages of the symptoms, the standard deviation, and the P values were calculated. RESULTS: Six hundred forty-five women who met the inclusion criteria were considered. In all the parameters examined (dyspareunia, vaginal orifice pain, dryness/atrophy, itching, burning, pH) statistically significant data were found between the pretreatment and the post-treatment (dryness: before = 8.30, after = 2.97 [P < 0.0001], dyspareunia: before = 8.70, after = 3.51 [P < 0.0001]; burning: before = 6.12, after = 1.78 [P < 0.0001]; vaginal orifice pain: before = 8.07, after = 2.94 [P < 0.0001]; itching: before = 6.09, after = 1.32 [P < 0.0001]). CONCLUSIONS: Our results show the effectiveness and a good degree of tolerance of treatment with the CO2 laser system in postmenopausal women with GSM.
OBJECTIVE:Genitourinary syndrome of menopause (GSM), especially vulvovaginal atrophy (VVA), is one of the most common conditions among women in either natural (4%-47%) or medically induced (23.4%-61.5%) menopause. The aims of this study are to assess the efficacy and effectiveness of CO2 laser in postmenopausal women with clinical signs and symptoms of GSM, in particular VVA, and to evaluate both possible early and late side effects related to this kind of treatment. METHODS: This retrospective, multicenter study was conducted after collecting data from a pre-existing database. We performed three to four CO2 laser treatments on all the women enrolled in this protocol. We used a fractional CO2 laser system (SmartXide VLR, Deka m.e.l.a., Florence, Italy) with a VulvoVaginal Laser Reshaping (VLR) scanning system and appropriate handpieces for the vaginal area. All women before and after the treatment were assessed. The pre- and post-treatment averages of the symptoms, the standard deviation, and the P values were calculated. RESULTS: Six hundred forty-five women who met the inclusion criteria were considered. In all the parameters examined (dyspareunia, vaginal orifice pain, dryness/atrophy, itching, burning, pH) statistically significant data were found between the pretreatment and the post-treatment (dryness: before = 8.30, after = 2.97 [P < 0.0001], dyspareunia: before = 8.70, after = 3.51 [P < 0.0001]; burning: before = 6.12, after = 1.78 [P < 0.0001]; vaginal orifice pain: before = 8.07, after = 2.94 [P < 0.0001]; itching: before = 6.09, after = 1.32 [P < 0.0001]). CONCLUSIONS: Our results show the effectiveness and a good degree of tolerance of treatment with the CO2 laser system in postmenopausal women with GSM.
Authors: Allison M Quick; Andrew Hundley; Cynthia Evans; Julie A Stephens; Bhuvaneswari Ramaswamy; Raquel E Reinbolt; Anne M Noonan; Jeffrey Bryan Van Deusen; Robert Wesolowski; Daniel G Stover; Nicole Olivia Williams; Sagar D Sardesai; Stephanie S Faubion; Charles L Loprinzi; Maryam B Lustberg Journal: J Clin Med Date: 2022-01-31 Impact factor: 4.241
Authors: Agnieszka Aleksandra Nalewczynska; Michael Barwijuk; Piotr Kolczewski; Ewa Dmoch-Gajzlerska Journal: Lasers Med Sci Date: 2021-08-12 Impact factor: 3.161