Literature DB >> 31793928

Adjuvant incorporated lipid nanoparticles for enhanced mRNA-mediated cancer immunotherapy.

Kyuri Lee1, Soo Young Kim1, Yunmi Seo1, Myung Hee Kim1, Jun Chang1, Hyukjin Lee1.   

Abstract

For mRNA mediated cancer immunotherapy, Pam3 was incorporated as an adjuvant within lipid nanoparticles (LNPs) with OVA mRNA. The developed Pam3 incorporated LNPs showed successful expression of tumor antigens with enhanced immune stimulation. We demonstrated that the synergies of Pam3 LNPs could greatly improve the efficacy of tumor prevention by mRNA vaccines.

Entities:  

Year:  2019        PMID： 31793928     DOI： 10.1039/c9bm01564g

Source DB:  PubMed          Journal:  Biomater Sci        ISSN： 2047-4830            Impact factor:   6.843


  8 in total

Review 1.  mRNA-based therapeutics: powerful and versatile tools to combat diseases.

Authors:  Shugang Qin; Xiaoshan Tang; Yuting Chen; Kepan Chen; Na Fan; Wen Xiao; Qian Zheng; Guohong Li; Yuqing Teng; Min Wu; Xiangrong Song
Journal:  Signal Transduct Target Ther       Date:  2022-05-21

2.  Exploring chitosan-shelled nanobubbles to improve HER2 + immunotherapy via dendritic cell targeting.

Authors:  Monica Argenziano; Sergio Occhipinti; Anna Scomparin; Costanza Angelini; Francesco Novelli; Marco Soster; Mirella Giovarelli; Roberta Cavalli
Journal:  Drug Deliv Transl Res       Date:  2022-06-07       Impact factor: 5.671

3.  Macrophage activation on "phagocytic synapse" arrays: Spacing of nanoclustered ligands directs TLR1/2 signaling with an intrinsic limit.

Authors:  Miao Li; Haomin Wang; Wenqian Li; Xiaoji G Xu; Yan Yu
Journal:  Sci Adv       Date:  2020-12-02       Impact factor: 14.136

Review 4.  Lipid Nanoparticles as Delivery Systems for RNA-Based Vaccines.

Authors:  Basmah N Aldosari; Iman M Alfagih; Alanood S Almurshedi
Journal:  Pharmaceutics       Date:  2021-02-02       Impact factor: 6.321

Review 5.  Lipid-Based Nanoparticles in the Clinic and Clinical Trials: From Cancer Nanomedicine to COVID-19 Vaccines.

Authors:  Thai Thanh Hoang Thi; Estelle J A Suys; Jung Seok Lee; Dai Hai Nguyen; Ki Dong Park; Nghia P Truong
Journal:  Vaccines (Basel)       Date:  2021-04-08

Review 6.  The Future of Tissue-Targeted Lipid Nanoparticle-Mediated Nucleic Acid Delivery.

Authors:  Ruvanthi N Kularatne; Rachael M Crist; Stephan T Stern
Journal:  Pharmaceuticals (Basel)       Date:  2022-07-20

Review 7.  Application of lipid-based nanoparticles in cancer immunotherapy.

Authors:  Zhongkun Zhang; Siyu Yao; Yingwen Hu; Xiaobin Zhao; Robert J Lee
Journal:  Front Immunol       Date:  2022-08-08       Impact factor: 8.786

Review 8.  Multifunctional Immunoadjuvants for Use in Minimalist Nucleic Acid Vaccines.

Authors:  Saed Abbasi; Satoshi Uchida
Journal:  Pharmaceutics       Date:  2021-05-01       Impact factor: 6.321
  8 in total

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