Identification of Anti-cancer Peptides Based on Multi-classifier System.

AIMS AND
OBJECTIVE: Cancer is one of the deadliest diseases, taking the lives of millions every year. Traditional methods of treating cancer are expensive and toxic to normal cells. Fortunately, anti-cancer peptides (ACPs) can eliminate this side effect. However, the identification and development of new anti-cancer peptides through experiments take a lot of time and money, therefore, it is necessary to develop a fast and accurate calculation model to identify the anti-cancer peptide. Machine learning algorithms are a good choice.
MATERIALS AND METHODS: In our study, a multi-classifier system was used, combined with multiple machine learning models, to predict anti-cancer peptides. These individual learners are composed of different feature information and algorithms, and form a multi-classifier system by voting. RESULTS AND
CONCLUSION: The experiments show that the overall prediction rate of each individual learner is above 80% and the overall accuracy of multi-classifier system for anti-cancer peptides prediction can reach 95.93%, which is better than the existing prediction model. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.