Alvino Bisecco1, Rocco Capuano2, Giuseppina Caiazzo1, Alessandro d'Ambrosio1, Renato Docimo2, Mario Cirillo1, Antonio Russo1, Manuela Altieri3, Simona Bonavita1, Maria A Rocca4, Massimo Filippi4, Gioacchino Tedeschi1, Antonio Gallo1. 1. Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli," Napoli, Italy/MRI Research Center, University of Campania "Luigi Vanvitelli" Napoli, Italy. 2. Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli" Napoli, Italy. 3. Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli," Napoli, Italy/Department of Psychology, University of Campania "Luigi Vanvitelli" Caserta, Italy. 4. Neurology Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy/Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Abstract
BACKGROUND: The relationship between cognitive performance and regional thalamic atrophy in multiple sclerosis (MS) has been investigated in recent studies. OBJECTIVE AND METHODS: To further assess this relationship, 118 relapsing-remitting MS patients and 52 healthy controls underwent a neuropsychological assessment and a 3T-MRI (3-Tesla magnetic resonance imaging). Cognitive performances were correlated with thalamic shape changes by using Vertex Analysis. RESULTS: Information processing speed performance correlated with atrophy of frontal/motor-connected thalamic sub-regions. Inhibitory control performance correlated with atrophy of all thalamic sub-regions. Global cognitive status correlated with atrophy of frontal/temporal-connected sub-regions. CONCLUSIONS: These findings support the hypothesis that, within the thalamus, the damage of the anterior regions is most relevant for cognitive dysfunction.
BACKGROUND: The relationship between cognitive performance and regional thalamic atrophy in multiple sclerosis (MS) has been investigated in recent studies. OBJECTIVE AND METHODS: To further assess this relationship, 118 relapsing-remitting MSpatients and 52 healthy controls underwent a neuropsychological assessment and a 3T-MRI (3-Tesla magnetic resonance imaging). Cognitive performances were correlated with thalamic shape changes by using Vertex Analysis. RESULTS: Information processing speed performance correlated with atrophy of frontal/motor-connected thalamic sub-regions. Inhibitory control performance correlated with atrophy of all thalamic sub-regions. Global cognitive status correlated with atrophy of frontal/temporal-connected sub-regions. CONCLUSIONS: These findings support the hypothesis that, within the thalamus, the damage of the anterior regions is most relevant for cognitive dysfunction.
Authors: A Dal-Bianco; R Schranzer; G Grabner; M Lanzinger; S Kolbrink; G Pusswald; P Altmann; M Ponleitner; M Weber; B Kornek; K Zebenholzer; C Schmied; T Berger; H Lassmann; S Trattnig; S Hametner; F Leutmezer; P Rommer Journal: Front Neurol Date: 2021-12-21 Impact factor: 4.003