| Literature DB >> 31792423 |
Pierre Pouget1, Ryad Benosman2,3, Serge Picaud4, Paul-Henri Prévot2, Kevin Gehere2, Fabrice Arcizet2, Himanshu Akolkar2, Mina A Khoei2, Kévin Blaize2, Omar Oubari2, Pierre Daye2, Marion Lanoë2, Manon Valet2, Sami Dalouz2, Paul Langlois2, Elric Esposito2, Valérie Forster2, Elisabeth Dubus2, Nicolas Wattiez1, Elena Brazhnikova2, Céline Nouvel-Jaillard2, Yannick LeMer5, Joanna Demilly6, Claire-Maëlle Fovet6, Philippe Hantraye6, Morgane Weissenburger1, Henri Lorach7, Elodie Bouillet8, Martin Deterre8, Ralf Hornig8, Guillaume Buc8, José-Alain Sahel2,5,3,9, Guillaume Chenegros2.
Abstract
Retinal dystrophies and age-related macular degeneration related to photoreceptor degeneration can cause blindness. In blind patients, although the electrical activation of the residual retinal circuit can provide useful artificial visual perception, the resolutions of current retinal prostheses have been limited either by large electrodes or small numbers of pixels. Here we report the evaluation, in three awake non-human primates, of a previously reported near-infrared-light-sensitive photovoltaic subretinal prosthesis. We show that multipixel stimulation of the prosthesis within radiation safety limits enabled eye tracking in the animals, that they responded to stimulations directed at the implant with repeated saccades and that the implant-induced responses were present two years after device implantation. Our findings pave the way for the clinical evaluation of the prosthesis in patients affected by dry atrophic age-related macular degeneration.Entities:
Mesh：
Year: 2019 PMID： 31792423 DOI： 10.1038/s41551-019-0484-2
Source DB: PubMed Journal: Nat Biomed Eng ISSN： 2157-846X Impact factor: 25.671