Literature DB >> 3179170

Plasma nitrendipine concentrations in elderly hypertensive patients after single and multiple dosing.

P Crome1, A Baksi, D MacMahon, N D Pandita-Gunawardena, J Edwards, J Marley.   

Abstract

Twenty-three elderly hypertensive subjects received nitrendipine 10mg daily by mouth for 8 days. Plasma nitrendipine concentrations were measured after the first and last dose. There was no significant difference in plasma concentrations at any time point between the two days nor in derived pharmacokinetic measurements. Drug accumulation was not observed.

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Year:  1988        PMID： 3179170      PMCID： PMC1386545          DOI： 10.1111/j.1365-2125.1988.tb05283.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  4 in total

1.  Age and the metabolism of drugs.

Authors:  M D Rawlins; O F James; F M Williams; H Wynne; K W Woodhouse
Journal:  Q J Med       Date:  1987-07

2.  Clinical experience with long-term nitrendipine treatment in essential hypertension.

Authors:  A Tourkantonis; A Lasaridis; L Settas
Journal:  J Cardiovasc Pharmacol       Date:  1984       Impact factor: 3.105

3.  Bioequivalence and metabolism of nitrendipine administered orally to healthy volunteers.

Authors:  J Kann; G J Krol; K D Raemsch; D E Burkholder; M J Levitt
Journal:  J Cardiovasc Pharmacol       Date:  1984       Impact factor: 3.105

4.  Steady-state pharmacokinetics of nitrendipine in hepatic insufficiency.

Authors:  K C Lasseter; E C Shamblen; A A Murdoch; D E Burkholder; G J Krol; R J Taylor; S K Vanov
Journal:  J Cardiovasc Pharmacol       Date:  1984       Impact factor: 3.105
  4 in total
  2 in total

1.  A comparison of the pharmacokinetics of nisoldipine in elderly and young subjects.

Authors:  A K Baksi; J S Edwards; G Ahr
Journal:  Br J Clin Pharmacol       Date:  1991-03       Impact factor: 4.335

Review 2.  Effects of cardiovascular disease on pharmacokinetics.

Authors:  V Rodighiero
Journal:  Cardiovasc Drugs Ther       Date:  1989-10       Impact factor: 3.727
  2 in total

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