| Literature DB >> 31790952 |
Carol D SanMartín1, Daniela Böhme2, Diego Rojas-Rivera3.
Abstract
Tumor necrosis factor alpha (TNF) triggers regulated necrosis of mycobacterium-infected macrophages through of mitochondrial reactive oxygen species (mitoROS) production in a RIPK1/3-dependent manner. To explain that, Roca and colleagues describe an inter-orgallenar circuit which involves the lysosomal ceramide production, mitoROS, BAX activation and RyR Ca2+ efflux from the endoplasmic reticulum into the mitochondrion.Entities:
Keywords: Calcium; Mycobacterium tuberculosis; ROS; Regulated necrosis; Ryanodine receptor; TNF
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Year: 2019 PMID： 31790952 DOI： 10.1016/j.ceca.2019.102113
Source DB: PubMed Journal: Cell Calcium ISSN： 0143-4160 Impact factor: 6.817