Wai Man Mandy Chan 1 , Yik Weng Yew 1 , Thiam Seng Colin Theng 2 , Choon Fong Liew 3 , Hazel H Oon 1 Show Affiliations »
Abstract
INTRODUCTION: Psoriasis is a chronic inflammatory condition that affects the skin and joints, and is associated with cardiovascular risk factors, including metabolic syndrome (MetS). We aimed to assess the prevalence of MetS in patients with psoriasis and determine whether there was a correlation between psoriasis severity and MetS in a Singapore population. METHODS: This was a cross-sectional study of patients with psoriasis, aged 18-69 years, who attended a tertiary dermatology referral centre in Singapore from October 2007 to February 2009. Fasting glucose, lipids, blood pressure, Psoriasis Area and Severity Index, and body mass index were measured. MetS was diagnosed in the presence of three or more criteria of the modified National Cholesterol Education Program Adult Treatment Panel III. RESULTS: Among 338 patients with psoriasis, there were 238 (70.4%) men and 100 (29.6%) women, who were Chinese (n = 228; 67.5%), Malay (n = 52; 15.4%) and Indian (n = 58; 17.2%). The prevalence of MetS was 45.1%. MetS was 44% more prevalent in patients older than 50 years (p = 0.02). Malay patients with psoriasis were significantly more likely to have hypertriglyceridaemia, elevated fasting plasma glucose and abdominal obesity. There was no significant correlation between psoriasis severity and risk of MetS. CONCLUSION: The prevalence of MetS in patients with psoriasis in Singapore was 45.1%, or nearly threefold higher than the Singapore general population. Patients with psoriasis should be screened yearly for MetS and any modifiable cardiovascular risk factors should be actively controlled. Copyright: © Singapore Medical Association.
INTRODUCTION: Psoriasis is a chronic inflammatory condition that affects the skin and joints, and is associated with cardiovascular risk factors, including metabolic syndrome (MetS ). We aimed to assess the prevalence of MetS in patients with psoriasis and determine whether there was a correlation between psoriasis severity and MetS in a Singapore population. METHODS: This was a cross-sectional study of patients with psoriasis , aged 18-69 years, who attended a tertiary dermatology referral centre in Singapore from October 2007 to February 2009. Fasting glucose , lipids, blood pressure, Psoriasis Area and Severity Index, and body mass index were measured. MetS was diagnosed in the presence of three or more criteria of the modified National Cholesterol Education Program Adult Treatment Panel III. RESULTS: Among 338 patients with psoriasis , there were 238 (70.4%) men and 100 (29.6%) women , who were Chinese (n = 228; 67.5%), Malay (n = 52; 15.4%) and Indian (n = 58; 17.2%). The prevalence of MetS was 45.1%. MetS was 44% more prevalent in patients older than 50 years (p = 0.02). Malay patients with psoriasis were significantly more likely to have hypertriglyceridaemia , elevated fasting plasma glucose and abdominal obesity . There was no significant correlation between psoriasis severity and risk of MetS . CONCLUSION: The prevalence of MetS in patients with psoriasis in Singapore was 45.1%, or nearly threefold higher than the Singapore general population. Patients with psoriasis should be screened yearly for MetS and any modifiable cardiovascular risk factors should be actively controlled. Copyright: © Singapore Medical Association.
Entities: Chemical
Disease
Species
Keywords:
Singapore; metabolic syndrome; psoriasis
Mesh： See more »
Year: 2019
PMID： 31788703 PMCID： PMC7905140 DOI： 10.11622/smedj.2019152
Source DB: PubMed Journal: Singapore Med J ISSN： 0037-5675 Impact factor: 1.858