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Literature DB >> 31787521

The Journey to Discovering a Flatworm Target of Praziquantel: A Long TRP.

Abstract

Infections caused by parasitic flatworms impose a considerable worldwide health burden. One of the most impactful is schistosomiasis, a disease caused by parasitic blood flukes. Treatment of schistosomiasis has relied on a single drug - praziquantel (PZQ) - for decades. The utility of PZQ as an essential medication is, however, intertwined with a stark gap in our knowledge as to how this drug works. No flatworm target has been identified that readily explains how PZQ paralyzes and damages schistosomes. Recently, a schistosome ion channel was discovered that is activated by PZQ and displays characteristics which mirror key features of PZQ action on schistosomes. Here, the journey to discovery of this target, properties of this ion channel, and remaining questions are reviewed.

Entities: CellLine Chemical Disease Gene Species

Keywords: anthelmintic; drug therapy; flatworm; schistosomiasis

Mesh：

Substances：

Year: 2019 PMID： 31787521 PMCID： PMC6937385 DOI： 10.1016/j.pt.2019.11.002

Source DB: PubMed Journal: Trends Parasitol ISSN： 1471-4922

89 in total

Review 1. Immunological involvement in the efficacy of praziquantel.

Authors: P J Brindley; A Sher
Journal: Exp Parasitol Date: 1990-08 Impact factor: 2.011

2. Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.

Authors: Ying Yin; Son C Le; Allen L Hsu; Mario J Borgnia; Huanghe Yang; Seok-Yong Lee
Journal: Science Date: 2019-02-07 Impact factor: 47.728

3. Praziquantel Targets M1 Macrophages and Ameliorates Splenomegaly in Chronic Schistosomiasis.

Authors: Delong Kong; Chunlei Zhou; Hongfei Guo; Wei Wang; Jingfan Qiu; Xinjian Liu; Jinfeng Liu; Lijuan Wang; Yong Wang
Journal: Antimicrob Agents Chemother Date: 2017-12-21 Impact factor: 5.191

4. Molecular basis of infrared detection by snakes.

Authors: Elena O Gracheva; Nicholas T Ingolia; Yvonne M Kelly; Julio F Cordero-Morales; Gunther Hollopeter; Alexander T Chesler; Elda E Sánchez; John C Perez; Jonathan S Weissman; David Julius
Journal: Nature Date: 2010-03-14 Impact factor: 49.962

5. Praziquantel, potassium and 2,4-dinitrophenol: analysis of their action on the musculature of Schistosoma mansoni.

Authors: R H Fetterer; R A Pax; J L Bennett
Journal: Eur J Pharmacol Date: 1980-05-30 Impact factor: 4.432

6. Light and scanning electron microscopy studies on the effects of the enantiomers of praziquantel and its main metabolite on Schistosoma mansoni in vitro.

Authors: U Staudt; G Schmahl; G Blaschke; H Mehlhorn
Journal: Parasitol Res Date: 1992 Impact factor: 2.289

Review 7. The unacknowledged impact of chronic schistosomiasis.

Authors: Charles H King; Madeline Dangerfield-Cha
Journal: Chronic Illn Date: 2008-03

8. New insight into the antifibrotic effects of praziquantel on mice in infection with Schistosoma japonicum.

Authors: Yue-Jin Liang; Jie Luo; Quan Yuan; Dan Zheng; Ya-Ping Liu; Lei Shi; Ying Zhou; Ai-Ling Chen; Yong-Ya Ren; Ke-Yi Sun; Yan Sun; Yong Wang; Zhao-Song Zhang
Journal: PLoS One Date: 2011-05-24 Impact factor: 3.240

9. Coalescing beneficial host and deleterious antiparasitic actions as an antischistosomal strategy.

Authors: John D Chan; Timothy A Day; Jonathan S Marchant
Journal: Elife Date: 2018-07-30 Impact factor: 8.140

10. A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors.

Authors: John D Chan; John D McCorvy; Sreemoyee Acharya; Malcolm E Johns; Timothy A Day; Bryan L Roth; Jonathan S Marchant
Journal: PLoS Pathog Date: 2016-05-17 Impact factor: 6.823

7 in total

1. Schistosome TRPML channels play a role in neuromuscular activity and tegumental integrity.

Authors: Swarna Bais; Abigail Norwillo; Gordon Ruthel; De'Broski R Herbert; Bruce D Freedman; Robert M Greenberg
Journal: Biochimie Date: 2022-01-03 Impact factor: 4.079

2. Mechanism of praziquantel action at a parasitic flatworm ion channel.

Authors: Sang-Kyu Park; Lukas Friedrich; Nawal A Yahya; Claudia M Rohr; Evgeny G Chulkov; David Maillard; Friedrich Rippmann; Thomas Spangenberg; Jonathan S Marchant
Journal: Sci Transl Med Date: 2021-12-22 Impact factor: 17.956

Review 3. Activation of transient receptor potential channel Sm.(Schistosoma mansoni)TRPM_PZQ by PZQ, enhanced Ca⁺⁺ influx, spastic paralysis, and tegumental disrupture-the deadly cascade in parasitic schistosomes, other trematodes, and cestodes.

Authors: Achim Harder
Journal: Parasitol Res Date: 2020-06-30 Impact factor: 2.289

The Journey to Discovering a Flatworm Target of Praziquantel: A Long TRP.

Review 1. Immunological involvement in the efficacy of praziquantel.

2. Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.

3. Praziquantel Targets M1 Macrophages and Ameliorates Splenomegaly in Chronic Schistosomiasis.

4. Molecular basis of infrared detection by snakes.

5. Praziquantel, potassium and 2,4-dinitrophenol: analysis of their action on the musculature of Schistosoma mansoni.

6. Light and scanning electron microscopy studies on the effects of the enantiomers of praziquantel and its main metabolite on Schistosoma mansoni in vitro.

Review 7. The unacknowledged impact of chronic schistosomiasis.

8. New insight into the antifibrotic effects of praziquantel on mice in infection with Schistosoma japonicum.

9. Coalescing beneficial host and deleterious antiparasitic actions as an antischistosomal strategy.

10. A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors.

1. Schistosome TRPML channels play a role in neuromuscular activity and tegumental integrity.

2. Mechanism of praziquantel action at a parasitic flatworm ion channel.

Review 3. Activation of transient receptor potential channel Sm.(Schistosoma mansoni)TRPM_PZQ by PZQ, enhanced Ca⁺⁺ influx, spastic paralysis, and tegumental disrupture-the deadly cascade in parasitic schistosomes, other trematodes, and cestodes.

Review 4. Schistosome TRP channels: An appraisal.

5. Identification of novel modulators of a schistosome transient receptor potential channel targeted by praziquantel.

Review 6. Trematode Proteomics: Recent Advances and Future Directions.

7. Metabolomics reveal alterations in arachidonic acid metabolism in Schistosoma mekongi after exposure to praziquantel.

Review 1. Immunological involvement in the efficacy of praziquantel.

Review 7. The unacknowledged impact of chronic schistosomiasis.

Review 3. Activation of transient receptor potential channel Sm.(Schistosoma mansoni)TRPMPZQ by PZQ, enhanced Ca++ influx, spastic paralysis, and tegumental disrupture-the deadly cascade in parasitic schistosomes, other trematodes, and cestodes.

Review 4. Schistosome TRP channels: An appraisal.

Review 6. Trematode Proteomics: Recent Advances and Future Directions.

Review 3. Activation of transient receptor potential channel Sm.(Schistosoma mansoni)TRPM_PZQ by PZQ, enhanced Ca⁺⁺ influx, spastic paralysis, and tegumental disrupture-the deadly cascade in parasitic schistosomes, other trematodes, and cestodes.