Shunjie Liu1, Junhao Pan2, Ke Tang1, Qingfeng Lei1, Lu He1, Yangyang Meng1, Xiaodong Cai1, Zhong Li3,4,5. 1. Department of Neurology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510655, China. 2. Department of Psychology, Sun Yat-sen University, Guangzhou, 510006, China. 3. Department of Neurology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510655, China. lzhong@mail.sysu.edu.cn. 4. Shenzhen Research Institute, Sun Yat-Sen University, Shenzhen, China. lzhong@mail.sysu.edu.cn. 5. Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, 510080, China. lzhong@mail.sysu.edu.cn.
Abstract
PURPOSE: Sleep disturbances are common in Alzheimer's disease (AD) and mild cognitive impairment (MCI) patients. Non-rapid eye movement stage 3 (N3), rapid eye movement stage (REM), spindle density, and K-complex (KC) density are decreased in MCI and AD patients. Periodic limb movements in sleep (PLMS) are increased in other neurodegenerative diseases. We aimed to distinguish amnestic mild cognitive impairment (aMCI) patients from the overall population of MCI patients by comparing the N3 and REM proportions, the morphological characteristics of spindles and KCs and the periodic limb movement index (PLMI) among control, aMCI and AD subjects. METHODS: In 92 subjects (30 controls, 32 aMCI and 30 AD), sleep stages, spindles, KCs and PLMS were recorded during the second of two nights of polysomnography (PSG). We compared the above parameters among the three groups. RESULTS: AD and aMCI subjects had lower proportions of N3 and REM, poorer spindle and KC activities and more frequent PLMS than controls. These alterations were associated with decreased Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores. We determined cut-off values for distinguishing aMCI and AD using logistic regression and receiver operating characteristic (ROC) analyses. CONCLUSIONS: AD and aMCI patients have abnormal sleep stage proportions, spindles, KCs and PLMS. The combination of the above alterations may distinguish aMCI and AD patients from controls with high specificity and sensitivity.
PURPOSE: Sleep disturbances are common in Alzheimer's disease (AD) and mild cognitive impairment (MCI) patients. Non-rapid eye movement stage 3 (N3), rapid eye movement stage (REM), spindle density, and K-complex (KC) density are decreased in MCI and ADpatients. Periodic limb movements in sleep (PLMS) are increased in other neurodegenerative diseases. We aimed to distinguish amnestic mild cognitive impairment (aMCI) patients from the overall population of MCI patients by comparing the N3 and REM proportions, the morphological characteristics of spindles and KCs and the periodic limb movement index (PLMI) among control, aMCI and AD subjects. METHODS: In 92 subjects (30 controls, 32 aMCI and 30 AD), sleep stages, spindles, KCs and PLMS were recorded during the second of two nights of polysomnography (PSG). We compared the above parameters among the three groups. RESULTS:AD and aMCI subjects had lower proportions of N3 and REM, poorer spindle and KC activities and more frequent PLMS than controls. These alterations were associated with decreased Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores. We determined cut-off values for distinguishing aMCI and AD using logistic regression and receiver operating characteristic (ROC) analyses. CONCLUSIONS:AD and aMCIpatients have abnormal sleep stage proportions, spindles, KCs and PLMS. The combination of the above alterations may distinguish aMCI and ADpatients from controls with high specificity and sensitivity.
Authors: E B Ukhinov; I M Madaeva; O N Berdina; L V Rychkova; L I Kolesnikova; S I Kolesnikov Journal: Bull Exp Biol Med Date: 2022-09-05 Impact factor: 0.737
Authors: Ye Zhang; Rong Ren; Linghui Yang; Haipeng Zhang; Yuan Shi; Hamid R Okhravi; Michael V Vitiello; Larry D Sanford; Xiangdong Tang Journal: Transl Psychiatry Date: 2022-04-01 Impact factor: 6.222