Literature DB >> 31786499

Increased inflammasome activity in markedly ill psychiatric patients: An explorative study.

Ulrika Hylén1, Daniel Eklund2, Mats Humble3, Jakub Bartoszek4, Eva Särndahl5, Susanne Bejerot6.   

Abstract

The aim of this study was to investigate inflammatory perturbations in 40 patients with severe and complex psychiatric disorders by studying the activity of the NLRP3 inflammasome, with a trans-diagnostic approach. Gene expression of CASP1, NLRP3, PYCARD, IL1B, IL1RN, TNF showed a significant increase in the patient group compared to a matched control group. Plasma levels of IL1Ra, IL-18, TNF, IL-6 and CRP were increased in the patient group. Within the patient group, increased gene expression of inflammatory markers correlated with increased disease severity. The findings support the inflammation hypothesis for markedly ill psychiatric patients across diagnostic groups.
Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

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Year:  2019        PMID： 31786499     DOI： 10.1016/j.jneuroim.2019.577119

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  6 in total

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5.  Clozapine Induces an Acute Proinflammatory Response That Is Attenuated by Inhibition of Inflammasome Signaling: Implications for Idiosyncratic Drug-Induced Agranulocytosis.

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6.  Potential Transdiagnostic Lipid Mediators of Inflammatory Activity in Individuals With Serious Mental Illness.

Authors:  Ulrika Hylén; Aidan McGlinchey; Matej Orešič; Susanne Bejerot; Mats B Humble; Eva Särndahl; Tuulia Hyötyläinen; Daniel Eklund
Journal:  Front Psychiatry       Date:  2021-11-26       Impact factor: 4.157
  6 in total

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