Literature DB >> 31784321

PEG-amino acid-przewaquinone a conjugations: Synthesis, physicochemical properties and protective effect in a rat model of brain ischemia-reperfusion.

Minghui Wang1, Ao Niu2, Zhibo Gong2, Zhengwen Xu2, Lili Li2, Bo Li3, Jinxin Wang4.   

Abstract

A total of 21 PEG-przewaquinone A conjugations with high drug loading ability, good water solubility and in vivo slow-release quality were obtained by conjugating przewaquinone A with PEG through amino acids and tripeptides spacers respectively. Notably, compound 3a can obviously reduce the brain ischemia-reperfusion damage dose-dependently in a rat model, which indicated the efficacy of our PEG prodrug strategy.
Copyright © 2019. Published by Elsevier Ltd.

Entities:  

Keywords:  Brain ischemia-reperfusion; Conjugation; Neuro-protective effect; PEG; Pharmacokinetic properties; Przewaquinone A; Tanshinone IIA

Year:  2019        PMID： 31784321     DOI： 10.1016/j.bmcl.2019.126780

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Effects of cyclosporin A pre-treatment combined with etomidate post-treatment on lung injury induced by limb ischemia-reperfusion in rats.

Authors:  Haibo Zou; Xiaofeng Sun
Journal:  J Int Med Res       Date:  2020-07       Impact factor: 1.671

2.  The expression and clinical significance of miRNA-183 in cerebral ischemia-reperfusion injury patients with cerebral small vessel disease.

Authors:  Zigen Liao; Hui Sun; Yanqun Chang; Hui Chen
Journal:  Ann Transl Med       Date:  2020-08
  2 in total

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