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Literature DB >> 3178315

Ultrastructural localisation of alkaline phosphatase activity in osteoarthritic human articular cartilage.

Abstract

The distribution of alkaline phosphatase activity in human articular cartilage from normal and osteoarthritic joints has been examined by an electron microscope technique, probably for the first time. In osteoarthritic cartilage chondrocytes and matrix vesicles close to the tidemark were positive for alkaline phosphatase activity. Large numbers of matrix vesicles were found within the extracellular matrix of osteoarthritic cartilage, and there is a specific relation between phosphatase activity, matrix vesicles, and initial mineral formation in the tidemark region of articular cartilage.

Entities: Disease Species

Mesh：

Substances：
Alkaline Phosphatase

Year: 1988 PMID： 3178315 PMCID： PMC1003591 DOI： 10.1136/ard.47.9.747

Source DB: PubMed Journal: Ann Rheum Dis ISSN： 0003-4967 Impact factor: 19.103

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3. FGF2 High Molecular Weight Isoforms Contribute to Osteoarthropathy in Male Mice.

Authors: Patience Meo Burt; Liping Xiao; Caroline Dealy; Melanie C Fisher; Marja M Hurley
Journal: Endocrinology Date: 2016-10-12 Impact factor: 4.736

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Authors: Frederic Cailotto; Pascal Reboul; Sylvie Sebillaud; Patrick Netter; Jean-Yves Jouzeau; Arnaud Bianchi
Journal: J Biol Chem Date: 2011-04-06 Impact factor: 5.157