Wei Zhao1, Li Zhang2, Guoliang Zhang2, Hamed Kord Varkaneh3, Jamal Rahmani4, Cain Clark5, Paul M Ryan6, Hebatullah M Abdulazeem7, Ammar Salehisahlabadi3. 1. Department of Obstetrics and Gynecology, Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao, 028000, Neimenggu, China. zhaoweia4@sina.com. 2. Department of Obstetrics and Gynecology, Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao, 028000, Neimenggu, China. 3. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 4. Department of Community Nutrition, Student Research Committee, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 5. Centre for Sport, Exercise and Life Sciences, Coventry University, Coventry, CV1 5FB, UK. 6. School of Medicine, University College Cork, Cork, Ireland. 7. Arab Diploma in Family Medicine, AICPD, Cairo, Egypt.
Abstract
AIMS: Relationship between liver enzymes such as gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), aspartate transaminase (AST) and alkaline phosphatase and risk of gestational diabetes mellitus (GDM) is a controversial issue. The aim of this systematic review and dose-response meta-analysis was to investigate the association between liver enzymes and risk of GDM in observational studies. METHODS: A comprehensive systematic literature search was conducted in MEDLINE/PubMed, SCOPUS and Web of Science databases up to September 2019. Combined odds ratios (ORs) with 95% confidence intervals (CIs) were evaluated by DerSimonian and Laird random-effects models. Dose-response analyses of these relationships were also carried out. RESULTS: Eight studies with 25,451 participants containing 2549 cases were included in this study. Pooled results showed a significant association between GGT levels and risk of GDM (OR 2.10, 95% CI 1.14-3.86, I2 84%). In addition, random-effects model indicated a dramatic and direct significant association between GGT and risk of GDM in nonlinear (p < 0.001) and linear (p < 0.001) dose-response analysis. Associations between ALT and AST with risk of GDM were found to be non-significant (OR 1.32, 95% CI 0.91-1.90, I2 65% and OR 0.76, 95% CI 0.52-1.10, I2 16%, respectively). CONCLUSION: This systematic review and dose-response meta-analysis highlights GGT as a significant and robust predictor of the incidence of GDM in pregnant women.
AIMS: Relationship between liver enzymes such as gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), aspartate transaminase (AST) and alkaline phosphatase and risk of gestational diabetes mellitus (GDM) is a controversial issue. The aim of this systematic review and dose-response meta-analysis was to investigate the association between liver enzymes and risk of GDM in observational studies. METHODS: A comprehensive systematic literature search was conducted in MEDLINE/PubMed, SCOPUS and Web of Science databases up to September 2019. Combined odds ratios (ORs) with 95% confidence intervals (CIs) were evaluated by DerSimonian and Laird random-effects models. Dose-response analyses of these relationships were also carried out. RESULTS: Eight studies with 25,451 participants containing 2549 cases were included in this study. Pooled results showed a significant association between GGT levels and risk of GDM (OR 2.10, 95% CI 1.14-3.86, I2 84%). In addition, random-effects model indicated a dramatic and direct significant association between GGT and risk of GDM in nonlinear (p < 0.001) and linear (p < 0.001) dose-response analysis. Associations between ALT and AST with risk of GDM were found to be non-significant (OR 1.32, 95% CI 0.91-1.90, I2 65% and OR 0.76, 95% CI 0.52-1.10, I2 16%, respectively). CONCLUSION: This systematic review and dose-response meta-analysis highlights GGT as a significant and robust predictor of the incidence of GDM in pregnant women.
Authors: Caroline A Crowther; Janet E Hiller; John R Moss; Andrew J McPhee; William S Jeffries; Jeffrey S Robinson Journal: N Engl J Med Date: 2005-06-12 Impact factor: 91.245
Authors: N H Cho; J E Shaw; S Karuranga; Y Huang; J D da Rocha Fernandes; A W Ohlrogge; B Malanda Journal: Diabetes Res Clin Pract Date: 2018-02-26 Impact factor: 5.602
Authors: Per Glud Ovesen; Jens Fuglsang; Mette Bisgaard Andersen; Charlotte Wolff; Olav Bjørn Petersen; H David McIntyre Journal: J Diabetes Res Date: 2018-03-15 Impact factor: 4.011
Authors: Manjunath Ramanjaneya; Alexandra E Butler; Meis Alkasem; Mohammed Bashir; Jayakumar Jerobin; Angela Godwin; Abu Saleh Md Moin; Lina Ahmed; Mohamed A Elrayess; Steven C Hunt; Stephen L Atkin; Abdul-Badi Abou-Samra Journal: Front Endocrinol (Lausanne) Date: 2021-03-30 Impact factor: 5.555
Authors: Samuel Kumi Okyere; Lei Xie; Juan Wen; Yinan Ran; Zhihua Ren; Junliang Deng; Yanchun Hu Journal: Nutrients Date: 2021-12-17 Impact factor: 5.717
Authors: Zhihua Ren; Samuel Kumi Okyere; Lei Xie; Juan Wen; Jiayi Wang; Zhengli Chen; Xueqin Ni; Junliang Deng; Yanchun Hu Journal: Front Immunol Date: 2022-02-15 Impact factor: 7.561