Dae Woo Kim1, Yong Min Kim2, Jin-Young Min3, Jeong-Whun Kim4, Jin-Kook Kim5, Ji-Hun Mo6, Jae-Min Shin7, Kyu-Sup Cho8, Sang Gyu Kwak9, Seung-Heon Shin10,11. 1. Department of Otolaryngology-Head and Neck Surgery, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, South Korea. 2. Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Chungnam National University, Daejeon, South Korea. 3. Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul, South Korea. 4. Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Seoul National University, Seoul, South Korea. 5. Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Konkuk University, Seoul, South Korea. 6. Department of Otolaryngology-Head and Neck Surgery, School of Medicine, College of Medicine, Dankook University, Cheonan, South Korea. 7. Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Korea University, Seoul, South Korea. 8. Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Pusan National University, Busan, South Korea. 9. Department of Medical Statistics, School of Medicine, Catholic University of Daegu, Gyeongsan, South Korea. 10. Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Catholic University of Daegu, Daegu, South Korea. hsseung@cu.ac.kr. 11. Department of Otorhinolaryngology, Daegu Catholic University Medical Center, 33 Duryugongwon-ro 17-gil, Nam-Gu, Daegu, 705-718, South Korea. hsseung@cu.ac.kr.
Abstract
PURPOSE: Fungus ball (FB) is the most common type of fungal rhinosinusitis and the prevalence of FB has increased over the past 10 years. The aim of this study was to compare the clinical characteristics of Korean adult patients with FB and chronic rhinosinusitis (CRS) without FB. METHODS: We retrospectively analyzed data on 1362 patients (147 FB and 1215 CRS) who underwent endoscopic sinus surgery at nine Korean medical centers in 2005, 2010, and 2016. We evaluated the prevalence of FB and compared the clinical characteristics of FB and CRS. Medical records, computed tomography (CT) findings, atopic status, concomitant diseases, tissue, and blood eosinophil count were assessed. RESULTS: The prevalence of FB was significantly higher in 2016 (15.9%) than in the other years (7.8% in 2005 and 7.5% in 2010). The FB patients were more likely to be female, older, have unilateral disease and less likely to have allergy compared to the CRS patients. The most common main complaint related to CRS and FB was nasal obstruction. CT determined that unilateral disease and maxillary sinus dominancy were common in patients with FB. The incidence of concomitant diseases was much higher in FB, with lower tissue and blood eosinophilia. CONCLUSION: FB is commonly encountered in older women with the increased prevalence. FB had a different clinical presentation, radiological findings, and prognosis than CRS. Further studies are needed to understand the pathophysiologic mechanisms underlying the development of FB.
PURPOSE: Fungus ball (FB) is the most common type of fungal rhinosinusitis and the prevalence of FB has increased over the past 10 years. The aim of this study was to compare the clinical characteristics of Korean adult patients with FB and chronic rhinosinusitis (CRS) without FB. METHODS: We retrospectively analyzed data on 1362 patients (147 FB and 1215 CRS) who underwent endoscopic sinus surgery at nine Korean medical centers in 2005, 2010, and 2016. We evaluated the prevalence of FB and compared the clinical characteristics of FB and CRS. Medical records, computed tomography (CT) findings, atopic status, concomitant diseases, tissue, and blood eosinophil count were assessed. RESULTS: The prevalence of FB was significantly higher in 2016 (15.9%) than in the other years (7.8% in 2005 and 7.5% in 2010). The FB patients were more likely to be female, older, have unilateral disease and less likely to have allergy compared to the CRS patients. The most common main complaint related to CRS and FB was nasal obstruction. CT determined that unilateral disease and maxillary sinus dominancy were common in patients with FB. The incidence of concomitant diseases was much higher in FB, with lower tissue and blood eosinophilia. CONCLUSION: FB is commonly encountered in older women with the increased prevalence. FB had a different clinical presentation, radiological findings, and prognosis than CRS. Further studies are needed to understand the pathophysiologic mechanisms underlying the development of FB.
Entities:
Keywords:
Chronic rhinosinusitis; Fungus ball; Multicenter study; Retrospective study
Authors: Antonio M Bulfamante; Carlotta Pipolo; Umberto D'Agostino Fiorenza; Flavio Arnone; Paolo Lozza; Giovanni Felisati; Alberto Maria Saibene Journal: Clin Case Rep Date: 2020-12-14