Fen Pan1, Yi Xu1, Weihua Zhou1, Jinkai Chen1, Ning Wei1, Shaojia Lu1, Desheng Shang2, Jinhui Wang3, Manli Huang4. 1. Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou, China. 2. Department of Radiology, First Affiliated Hospital, College of Medicine, Zhejiang University, The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou, China. 3. Institute for Brain Research and Rehabilitation, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, South China Normal University, Guangzhou, China. Electronic address: jinhui.wang.1982@m.scnu.edu.cn. 4. Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou, China. Electronic address: huangmanli@zju.edu.cn.
Abstract
BACKGROUND: Previous neuroimaging studies have showed that imbalanced functional integration of distributed large-scale brain networks is associated with pathophysiological characteristics of major depressive disorder (MDD). However, the association between network integrative disturbances and clinical features and cognitive functions remains largely unclear in adolescent MDD. This study investigated the neural correlates of abnormal functional connectivity networks with clinical and cognitive characteristics in adolescent MDD. METHODS: Twenty-eight first-episode, treatment-naive adolescents with MDD and 24 well-matched healthy controls (HCs) underwent functional magnetic resonance imaging (fMRI) and a battery of cognitive tests. A seed-based functional connectivity (FC) approach was used to depict connectivity patterns of the cognitive control network (CCN), affective network (AN) and default mode network (DMN), whose between-group differences were correlated with clinical variables and cognitive functions in the patients. RESULTS: Compared with the HCs, the MDD patients exhibited impaired executive functions. The FC analysis revealed lower CCN FC with the temporal, parietal and frontal regions and the limbic system, higher AN FC with the temporal and occipital regions and the cerebellum, and lower DMN FC with the cerebellum and insula. Interestingly, the decreased CCN FC was related to disease severity (with the inferior frontal gyrus) and executive dysfunctions (with the middle cingulate gyrus and supramarginal gyrus) in the patients. LIMITATIONS: The main limitations were the relatively small sample size and suboptimal imaging parameters. CONCLUSION: Functional alteration of CCN during the developmentally sensitive period may be important in the neurobiology of adolescent MDD.
BACKGROUND: Previous neuroimaging studies have showed that imbalanced functional integration of distributed large-scale brain networks is associated with pathophysiological characteristics of major depressive disorder (MDD). However, the association between network integrative disturbances and clinical features and cognitive functions remains largely unclear in adolescent MDD. This study investigated the neural correlates of abnormal functional connectivity networks with clinical and cognitive characteristics in adolescent MDD. METHODS: Twenty-eight first-episode, treatment-naive adolescents with MDD and 24 well-matched healthy controls (HCs) underwent functional magnetic resonance imaging (fMRI) and a battery of cognitive tests. A seed-based functional connectivity (FC) approach was used to depict connectivity patterns of the cognitive control network (CCN), affective network (AN) and default mode network (DMN), whose between-group differences were correlated with clinical variables and cognitive functions in the patients. RESULTS: Compared with the HCs, the MDD patients exhibited impaired executive functions. The FC analysis revealed lower CCN FC with the temporal, parietal and frontal regions and the limbic system, higher AN FC with the temporal and occipital regions and the cerebellum, and lower DMN FC with the cerebellum and insula. Interestingly, the decreased CCN FC was related to disease severity (with the inferior frontal gyrus) and executive dysfunctions (with the middle cingulate gyrus and supramarginal gyrus) in the patients. LIMITATIONS: The main limitations were the relatively small sample size and suboptimal imaging parameters. CONCLUSION: Functional alteration of CCN during the developmentally sensitive period may be important in the neurobiology of adolescent MDD.
Authors: Dmitry D Bezmaternykh; Mikhail Ye Melnikov; Andrey A Savelov; Lyudmila I Kozlova; Evgeniy D Petrovskiy; Kira A Natarova; Mark B Shtark Journal: Neural Plast Date: 2021-01-15 Impact factor: 3.599
Authors: Jari Peräkylä; Kaija Järventausta; Piia Haapaniemi; Joan A Camprodon; Kaisa M Hartikainen Journal: Front Psychiatry Date: 2021-07-02 Impact factor: 4.157