Tatiane Souza Soares Oliveira1,2, Rosana Cristina Pereira de Andrade1,2, Dislene Nascimento Dos Santos1, Keith Froes Orrico2, José Abraão Neto2, Cassius José Vitor de Oliveira2, Paulo Novis Rocha3, Edgar Marcelino de Carvalho2,4,5. 1. Universidade Federal da Bahia, Complexo Hospitalar Professor Edgard Santos, Departamento de Reabilitação, Salvador, BA, Brasil. 2. Universidade Federal da Bahia, Complexo Hospitalar Professor Edgard Santos, Departamento de Imunologia, Salvador, BA, Brasil. 3. Universidade Federal da Bahia, Escola de Medicina, Departamento de Medicina Interna e Apoio Diagnóstico, Salvador, BA, Brasil. 4. Fundação Oswaldo Cruz-Bahia, Instituto Gonçalo Moniz, Laboratório de Pesquisas Clínicas, Salvador, BA, Brasil. 5. Ministério da Ciência, Tecnologia, Inovações e Comunicações, Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Salvador, BA, Brasil.
Abstract
INTRODUCTION: Bowel dysfunction is frequent in patients with spinal cord diseases, but little is known about the prevalence of bowel symptoms in human T-lymphotropic virus-(HTLV-1) infected individuals. The purpose of this study is to determine the frequency of bowel symptoms in HTLV-1 infected individuals and their correlation with the degree of neurologic disease. METHODS: This is a cross-sectional study comparing the frequency of bowel symptoms in HTLV-1-infected individuals* and seronegative donors (controls). Patients answered a questionnaire, the Rome III Criteria was applied, and stool consistency was evaluated by the Bristol Stool Form Scale. The individuals were classified as HTLV-1 carriers, probable HTLV-1 myelopathy and definitive HTLV-1 associated myelopathy or tropical spastic paraparesis (definitive HAM / TSP)**. RESULTS: We studied 72 HTLV-1 infected individuals and 72 controls with equal age and gender distribution. Constipation was the most frequent complaint, occurring in 38 % of HTLV-1 individuals and in 15 % of the controls. In comparison to the seronegative controls, the probability of constipation occurrence was approximately 18 times higher in definitive HAM / TSP patients. Straining, lumpy or hard stools, sensation of anorectal obstruction/blockage, fewer than 3 defecations per week, flatulence, soiling, evacuation pain, and bleeding were also more frequent in the HTLV-1 patients than in the controls. Moreover, bowel symptoms were more frequent in patients with definitive or probable HAM / TSP than in carriers. CONCLUSIONS: Bowel symptoms were more frequent in HTLV-1-infected patients than in seronegative controls and the frequency of bowel symptoms correlated with the severity of neurologic disease.
INTRODUCTION: Bowel dysfunction is frequent in patients with spinal cord diseases, but little is known about the prevalence of bowel symptoms in human T-lymphotropic virus-(HTLV-1) infected individuals. The purpose of this study is to determine the frequency of bowel symptoms in HTLV-1 infected individuals and their correlation with the degree of neurologic disease. METHODS: This is a cross-sectional study comparing the frequency of bowel symptoms in HTLV-1-infected individuals* and seronegative donors (controls). Patients answered a questionnaire, the Rome III Criteria was applied, and stool consistency was evaluated by the Bristol Stool Form Scale. The individuals were classified as HTLV-1 carriers, probable HTLV-1 myelopathy and definitive HTLV-1 associated myelopathy or tropical spastic paraparesis (definitive HAM / TSP)**. RESULTS: We studied 72 HTLV-1 infected individuals and 72 controls with equal age and gender distribution. Constipation was the most frequent complaint, occurring in 38 % of HTLV-1 individuals and in 15 % of the controls. In comparison to the seronegative controls, the probability of constipation occurrence was approximately 18 times higher in definitive HAM / TSPpatients. Straining, lumpy or hard stools, sensation of anorectal obstruction/blockage, fewer than 3 defecations per week, flatulence, soiling, evacuation pain, and bleeding were also more frequent in the HTLV-1patients than in the controls. Moreover, bowel symptoms were more frequent in patients with definitive or probable HAM / TSP than in carriers. CONCLUSIONS:Bowel symptoms were more frequent in HTLV-1-infectedpatients than in seronegative controls and the frequency of bowel symptoms correlated with the severity of neurologic disease.
Authors: Bernardo Galvão-Castro; Maria Fernanda Rios Grassi; Ana Verena Galvão-Castro; Aidê Nunes; Ana Karina Galvão-Barroso; Thessika Hialla Almeida Araújo; Regina Helena Rathsam-Pinheiro; Ceuci Lima Xavier Nunes; Adriele Ribeiro; Monique Lírio; Noilson Lázaro Gonçalves; Sônia Lúcia Rangel; Cristiane Maria Carvalho Costa Dias; Daniele Piai Ozores; Selena Márcia Dubois-Mendes; Isabela Lima; André Luís Pereira Silva; Washington Luiz Abreu de Jesus; Fred Luciano Neves Santos; José Guilherme Reis de Oliveira; Yscela Vanessa Pimentel de Moraes; Adijeane Oliveira de Jesus; Francisco Daltro; Ney Boa-Sorte; Humberto Castro-Lima; Maria Luísa Carvalho Soliani Journal: Front Med (Lausanne) Date: 2022-06-07
Authors: Ricardo Ishak; Marluísa de Oliveira Guimarães Ishak; Vânia Nakauth Azevedo; Luiz Fernando Almeida Machado; Izaura Maria Cayres Vallinoto; Maria Alice Freitas Queiroz; Greice de Lemos Cardoso Costa; João Farias Guerreiro; Antonio Carlos Rosário Vallinoto Journal: Virus Evol Date: 2020-07-24