| Literature DB >> 31777549 |
José Miguel Flores-Fernández1,2, Eduardo Padilla-Camberos3, Ofelia Fernández-Flores3, Nestor Emmanuel Diaz-Martínez3, Carla Patricia Barragán-Álvarez3, Patricia Berenice Ramírez-Rodríguez3.
Abstract
Eupatorium aschenbornianum has been widely used in traditional Mexican and folk medicine for the treatment of wounds, skin lesions, hemorrhages and gastric ulcers in humans. Phytochemical studies have indicated that hexane extracts of E. aschenbornianum have anti-microbial and anti-fungal activities. In the present study, an accurate and reliable approach using a murine model was pursued to evaluate the anti-ulcer activity, lipid peroxidation properties and acute toxicity of powdered dried stem of E. aschenbornianum. The results indicated that administration of E. aschenbornianum exerted an anti-ulcerative effect and decreased lipid peroxidation in gastric ulcers induced by acetylsalicylic acid. An acute toxicity assay indicated normal behavior and no significant variations in the weight and food consumption of animals. In addition, quantitative analysis of biochemical parameters did not indicate any liver or kidney damage. The results indicated that E. aschenbornianum may be a safe therapeutic agent for the prevention of gastric ulcers.Entities:
Keywords: Eupatorium aschenbornianum; acute toxicity; anti-ulcerative activity; gastric lesions; gastroprotective effect
Year: 2019 PMID： 31777549 PMCID： PMC6862456 DOI： 10.3892/etm.2019.8093
Source DB: PubMed Journal: Exp Ther Med ISSN： 1792-0981 Impact factor: 2.447