Nicolás von Ellenrieder1, Jean Gotman1, Rina Zelmann1,2, Christine Rogers1, Dang Khoa Nguyen3, Philippe Kahane4, François Dubeau1, Birgit Frauscher1,5. 1. Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada. 2. Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA. 3. University of Montreal Hospital Center, Montreal, Quebec, Canada. 4. Department of Neurology, Grenoble-Alpes University Hospital and Grenoble-Alpes University, Grenoble, France. 5. Department of Medicine, Queen's University, Kingston, Ontario, Canada.
Abstract
OBJECTIVE: Regional variations in oscillatory activity during human sleep remain unknown. Using the unique ability of intracranial electroencephalography to study in situ brain physiology, this study assesses regional variations of electroencephalographic sleep activity and creates the first atlas of human sleep using recordings from the first sleep cycle. METHODS: Intracerebral electroencephalographic recordings with channels displaying physiological activity from nonlesional tissue were selected from 91 patients of 3 tertiary epilepsy centers. Sections during non-rapid eye movement sleep (stages N2 and N3) and rapid eye movement sleep (stage R) were selected from the first sleep cycle for oscillatory and nonoscillatory signal analysis. Results of 1,468 channels were grouped into 38 regions covering all cortical areas. RESULTS: We found regional differences in the distribution of sleep transients and spectral content during all sleep stages. There was a caudorostral gradient, with more slow frequencies and fewer spindles in temporoparieto-occipital than in frontal cortex. Moreover, deep-seated structures showed spectral peaks differing from the baseline electroencephalogram. The regions with >60% of channels presenting significant rhythmic activity were either mesial or temporal basal structures that contribute minimally to the scalp electroencephalogram. Finally, during deeper sleep stages, electroencephalographic analysis revealed a more homogeneous spatial distribution, with increased coupling between high and low frequencies. INTERPRETATION: This study provides a better understanding of the regional variability of sleep, and establishes a baseline for human sleep in all cortical regions during the first sleep cycle. Furthermore, the open-access atlas will be a unique resource for research (https://mni-open-ieegatlas. RESEARCH: mcgill.ca). ANN NEUROL 2020;87:289-301.
OBJECTIVE: Regional variations in oscillatory activity during human sleep remain unknown. Using the unique ability of intracranial electroencephalography to study in situ brain physiology, this study assesses regional variations of electroencephalographic sleep activity and creates the first atlas of human sleep using recordings from the first sleep cycle. METHODS: Intracerebral electroencephalographic recordings with channels displaying physiological activity from nonlesional tissue were selected from 91 patients of 3 tertiary epilepsy centers. Sections during non-rapid eye movement sleep (stages N2 and N3) and rapid eye movement sleep (stage R) were selected from the first sleep cycle for oscillatory and nonoscillatory signal analysis. Results of 1,468 channels were grouped into 38 regions covering all cortical areas. RESULTS: We found regional differences in the distribution of sleep transients and spectral content during all sleep stages. There was a caudorostral gradient, with more slow frequencies and fewer spindles in temporoparieto-occipital than in frontal cortex. Moreover, deep-seated structures showed spectral peaks differing from the baseline electroencephalogram. The regions with >60% of channels presenting significant rhythmic activity were either mesial or temporal basal structures that contribute minimally to the scalp electroencephalogram. Finally, during deeper sleep stages, electroencephalographic analysis revealed a more homogeneous spatial distribution, with increased coupling between high and low frequencies. INTERPRETATION: This study provides a better understanding of the regional variability of sleep, and establishes a baseline for human sleep in all cortical regions during the first sleep cycle. Furthermore, the open-access atlas will be a unique resource for research (https://mni-open-ieegatlas. RESEARCH: mcgill.ca). ANN NEUROL 2020;87:289-301.
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Authors: Anli A Liu; Simon Henin; Saman Abbaspoor; Anatol Bragin; Elizabeth A Buffalo; Jordan S Farrell; David J Foster; Loren M Frank; Tamara Gedankien; Jean Gotman; Jennifer A Guidera; Kari L Hoffman; Joshua Jacobs; Michael J Kahana; Lin Li; Zhenrui Liao; Jack J Lin; Attila Losonczy; Rafael Malach; Matthijs A van der Meer; Kathryn McClain; Bruce L McNaughton; Yitzhak Norman; Andrea Navas-Olive; Liset M de la Prida; Jon W Rueckemann; John J Sakon; Ivan Skelin; Ivan Soltesz; Bernhard P Staresina; Shennan A Weiss; Matthew A Wilson; Kareem A Zaghloul; Michaël Zugaro; György Buzsáki Journal: Nat Commun Date: 2022-10-12 Impact factor: 17.694