Jose L Gomez1. 1. Pulmonary, Critical Care and Sleep, Yale University School of Medicine, 300 Cedar Street, New Haven, CT, 06520, USA. jose.gomez-villalobos@yale.edu.
Abstract
PURPOSE OF REVIEW: Asthma is one of the most common chronic respiratory diseases linked with increased morbidity and healthcare utilization. The underlying pathophysiological processes and causal relationships of asthma with epigenetic mechanisms are partially understood. Here we review human studies of epigenetic mechanisms in asthma, with a special focus on DNA methylation. RECENT FINDINGS: Epigenetic studies of childhood asthma have identified specific methylation signatures associated with allergic inflammation in the airway and immune cells, demonstrating a regulatory role for methylation in asthma pathogenesis. Despite these novel findings, additional research in the role of epigenetic mechanisms underlying asthma endotypes is needed. Similarly, studies of histone modifications are also lacking in asthma. Future studies of epigenetic mechanisms in asthma will benefit from data integration in well phenotyped cohorts. This review provides an overview of the current literature on epigenetic studies in human asthma, with special emphasis on methylation and childhood asthma.
PURPOSE OF REVIEW: Asthma is one of the most common chronic respiratory diseases linked with increased morbidity and healthcare utilization. The underlying pathophysiological processes and causal relationships of asthma with epigenetic mechanisms are partially understood. Here we review human studies of epigenetic mechanisms in asthma, with a special focus on DNA methylation. RECENT FINDINGS: Epigenetic studies of childhood asthma have identified specific methylation signatures associated with allergic inflammation in the airway and immune cells, demonstrating a regulatory role for methylation in asthma pathogenesis. Despite these novel findings, additional research in the role of epigenetic mechanisms underlying asthma endotypes is needed. Similarly, studies of histone modifications are also lacking in asthma. Future studies of epigenetic mechanisms in asthma will benefit from data integration in well phenotyped cohorts. This review provides an overview of the current literature on epigenetic studies in humanasthma, with special emphasis on methylation and childhood asthma.
Authors: Eva Morales; Mariona Bustamante; Nadia Vilahur; Georgia Escaramis; Magda Montfort; Rafael de Cid; Raquel Garcia-Esteban; Maties Torrent; Xavier Estivill; Joan O Grimalt; Jordi Sunyer Journal: Am J Respir Crit Care Med Date: 2012-02-09 Impact factor: 21.405
Authors: Ivana V Yang; Brent S Pedersen; Andrew Liu; George T O'Connor; Stephen J Teach; Meyer Kattan; Rana Tawil Misiak; Rebecca Gruchalla; Suzanne F Steinbach; Stanley J Szefler; Michelle A Gill; Agustin Calatroni; Gloria David; Corinne E Hennessy; Elizabeth J Davidson; Weiming Zhang; Peter Gergen; Alkis Togias; William W Busse; David A Schwartz Journal: J Allergy Clin Immunol Date: 2015-03-11 Impact factor: 10.793
Authors: Bettina Levänen; Nirav R Bhakta; Patricia Torregrosa Paredes; Rebecca Barbeau; Stefanie Hiltbrunner; Joshua L Pollack; C Magnus Sköld; Magnus Svartengren; Johan Grunewald; Susanne Gabrielsson; Anders Eklund; Britt-Marie Larsson; Prescott G Woodruff; David J Erle; Åsa M Wheelock Journal: J Allergy Clin Immunol Date: 2013-01-16 Impact factor: 10.793
Authors: Owen D Solberg; Edwin J Ostrin; Michael I Love; Jeffrey C Peng; Nirav R Bhakta; Lydia Hou; Christine Nguyen; Margaret Solon; Cindy Nguyen; Andrea J Barczak; Lorna T Zlock; Denitza P Blagev; Walter E Finkbeiner; K Mark Ansel; Joseph R Arron; David J Erle; Prescott G Woodruff Journal: Am J Respir Crit Care Med Date: 2012-09-06 Impact factor: 21.405
Authors: S J Barton; S Ngo; P Costello; E Garratt; S El-Heis; E Antoun; R Clarke-Harris; R Murray; T Bhatt; G Burdge; C Cooper; H Inskip; E M van der Beek; A Sheppard; K M Godfrey; K A Lillycrop Journal: Clin Exp Allergy Date: 2017-08-31 Impact factor: 5.018
Authors: Dorota Stefanowicz; Tillie-Louise Hackett; Farshid S Garmaroudi; Oliver P Günther; Sarah Neumann; Erika N Sutanto; Kak-Ming Ling; Michael S Kobor; Anthony Kicic; Stephen M Stick; Peter D Paré; Darryl A Knight Journal: PLoS One Date: 2012-09-06 Impact factor: 3.240
Authors: Ryan Arathimos; Matthew Suderman; Gemma C Sharp; Kimberley Burrows; Raquel Granell; Kate Tilling; Tom R Gaunt; John Henderson; Susan Ring; Rebecca C Richmond; Caroline L Relton Journal: Clin Epigenetics Date: 2017-10-13 Impact factor: 6.551
Authors: Kai Sen Tan; Rachel Liyu Lim; Jing Liu; Hsiao Hui Ong; Vivian Jiayi Tan; Hui Fang Lim; Kian Fan Chung; Ian M Adcock; Vincent T Chow; De Yun Wang Journal: Front Cell Dev Biol Date: 2020-02-25