Aluru Rammohan1,2, Guda Mallikarjuna Reddy3, Baki Vijaya Bhaskar4, Duvvuru Gunasekar5, Grigory V Zyryanov3,6. 1. Department of Organic and Biomolecular Chemistry, Ural Federal University, Chemical Engineering Institute, 19 Mira St, Yekaterinburg, 620002, Russian Federation. RAluru@urfu.ru. 2. Natural Products Division, Department of Chemistry, Sri Venkateswara University, Tirupati, India. RAluru@urfu.ru. 3. Department of Organic and Biomolecular Chemistry, Ural Federal University, Chemical Engineering Institute, 19 Mira St, Yekaterinburg, 620002, Russian Federation. 4. Department of Pathophysiology, The Key Immunopathology Laboratory of Guangdong Province, Shantou University Medical College, Shantou, 515031, Guangdong Province, China. 5. Natural Products Division, Department of Chemistry, Sri Venkateswara University, Tirupati, India. 6. Ural Division of the Russian Academy of Sciences, I. Ya, Postovskiy Institute of Organic Synthesis, 22 S. Kovalevskoy Street, Yekaterinburg, Russian Federation.
Abstract
MAIN CONCLUSION: The genus Rhynchosia is a rich source of natural compounds especially flavonoids and prenylated isoflavonoids. Further experimental studies on Rhynchosia members may be result new and novel secondary metabolites with potent biological activities. Traditionally, medicinal plants have played a significant role on human life since ancient days. At present, natural compounds are the major source for the modern drug discovery owing to their therapeutic selectivity, minutest of side effects, inexpensive source and serve as lead molecules for the discovery of new drugs. Rhynchosia species (Fabaceae) are extensively circulated throughout the tropical and subtropical areas around the world. A few plants of this genus were used in traditional medicine for the treatment of various ailments such as antibacterial, antidiabetic, abortifacients, healing of wounds, hepatoprotective, remedial of boils, rheumatic pains and skin infections. The present review compiles traditional uses, isolated chemical compounds and pharmacological activities of Rhynchosia species. So far, in total, seventy-seven compounds were isolated from the genus Rhynchosia, including flavonoids, isoflavonoids, flavan-3-ols, xanthones, biphenyls, simple polyphenols and sterols. It is interesting to note that the genus Rhynchosia is a rich source of C-glycosylflavonoids and prenylated isoflavonoids. Further, phytochemical and pharmacological studies on this genus are required since only few species have been investigated so far.
MAIN CONCLUSION: The genus Rhynchosia is a rich source of natural compounds especially flavonoids and prenylated isoflavonoids. Further experimental studies on Rhynchosia members may be result new and novel secondary metabolites with potent biological activities. Traditionally, medicinal plants have played a significant role on human life since ancient days. At present, natural compounds are the major source for the modern drug discovery owing to their therapeutic selectivity, minutest of side effects, inexpensive source and serve as lead molecules for the discovery of new drugs. Rhynchosia species (Fabaceae) are extensively circulated throughout the tropical and subtropical areas around the world. A few plants of this genus were used in traditional medicine for the treatment of various ailments such as antibacterial, antidiabetic, abortifacients, healing of wounds, hepatoprotective, remedial of boils, rheumatic pains and skin infections. The present review compiles traditional uses, isolated chemical compounds and pharmacological activities of Rhynchosia species. So far, in total, seventy-seven compounds were isolated from the genus Rhynchosia, including flavonoids, isoflavonoids, flavan-3-ols, xanthones, biphenyls, simple polyphenols and sterols. It is interesting to note that the genus Rhynchosia is a rich source of C-glycosylflavonoids and prenylated isoflavonoids. Further, phytochemical and pharmacological studies on this genus are required since only few species have been investigated so far.
Entities:
Keywords:
Flavonoids; Pharmacology; Phytochemistry; Rhynchosia; Traditional medicine
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