| Literature DB >> 31776331 |
Caleb R Perez1, Michele De Palma2.
Abstract
At the interface between the innate and adaptive immune system, dendritic cells (DCs) play key roles in tumour immunity and hold a hitherto unrealized potential for cancer immunotherapy. Here we review the role of distinct DC subsets in the tumour microenvironment, with special emphasis on conventional type 1 DCs. Integrating new knowledge of DC biology and advancements in cell engineering, we provide a blueprint for the rational design of optimized DC vaccines for personalized cancer medicine.Entities:
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Year: 2019 PMID： 31776331 PMCID： PMC6881351 DOI： 10.1038/s41467-019-13368-y
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919