Mabel Cristina Paiva Machado da Silva1, Manuela de Andrade Arnaud2, Maria Carlla Aroucha Lyra3, Arnoldo Vasconcelos de Alencar Filho4, Maria Ângela Wanderley Rocha5, Regina Coeli Ferreira Ramos6, Vanessa Van Der Linden7, Arnaldo de França Caldas8, Monica Vilela Heimer9, Aronita Rosenblatt10. 1. University of Pernambuco, School of Dentistry - Department of Pediatric Dentistry, Camaragibe, Pernambuco, Brazil. Electronic address: belpaivamachado@gmail.com. 2. University of Pernambuco, School of Dentistry - Department of Pediatric Dentistry, Camaragibe, Pernambuco, Brazil. Electronic address: manuelaarnaud@gmail.com. 3. University of Pernambuco, School of Dentistry - Department of Pediatric Dentistry, Camaragibe, Pernambuco, Brazil. Electronic address: mcarllalyra@gmail.com. 4. University of Pernambuco, School of Dentistry - Department of Pediatric Dentistry, Camaragibe, Pernambuco, Brazil. Electronic address: arnoldoalencar@gmail.com. 5. University of Pernambuco, School of Medicine - Department of Infectious Disease, Recife, Pernambuco, Brazil. Electronic address: mangelarocha@uol.com.br. 6. University of Pernambuco, School of Medicine - Department of Infectious Disease, Recife, Pernambuco, Brazil. Electronic address: rcoeliramos@gmail.com. 7. AACD - Brazilian Association for the Welfare of the Handicapped Children, Recife, Pernambuco, Brazil. Electronic address: vanessavdl@hotmail.com. 8. University of Pernambuco, School of Dentistry - Department of Pediatric Dentistry, Camaragibe, Pernambuco, Brazil. Electronic address: caldasfjr@alldeia.com.br. 9. University of Pernambuco, School of Dentistry - Department of Pediatric Dentistry, Camaragibe, Pernambuco, Brazil. Electronic address: monica@heimer.com. 10. University of Pernambuco, School of Dentistry - Department of Pediatric Dentistry, Camaragibe, Pernambuco, Brazil. Electronic address: aronitarosenblatt@gmail.com.
Abstract
BACKGROUND: In Brazil, in October 2015, an outbreak of Zika virus (ZIKV) infection and an increase in newborns with microcephaly suggested a relationship between maternal infection and microcephaly in children. OBJECTIVE: First, to assess the presence of dental bud sin 13 infants with a confirmed diagnosis of congenital ZIKV syndrome, born to mothers infected with the virus during pregnancy; second, to evaluate the dental development of these children at a 36-month follow-up. DESIGN: Case-based longitudinal study. RESULTS: Dental radiographs in the first semester showed that all children had dental buds. Along with the study, the individuals presented with various dental disturbances. At the end of the evaluation period, some children still had incomplete deciduous dentition. CONCLUSION: The abnormal chronology of dental eruption and dental development disturbances in children with microcephaly infected with ZIKV born to infected mothers indicate a possible role of the virus in odontogenesis.
BACKGROUND: In Brazil, in October 2015, an outbreak of Zika virus (ZIKV) infection and an increase in newborns with microcephaly suggested a relationship between maternal infection and microcephaly in children. OBJECTIVE: First, to assess the presence of dental bud sin 13 infants with a confirmed diagnosis of congenital ZIKV syndrome, born to mothers infected with the virus during pregnancy; second, to evaluate the dental development of these children at a 36-month follow-up. DESIGN: Case-based longitudinal study. RESULTS: Dental radiographs in the first semester showed that all children had dental buds. Along with the study, the individuals presented with various dental disturbances. At the end of the evaluation period, some children still had incomplete deciduous dentition. CONCLUSION: The abnormal chronology of dental eruption and dental development disturbances in children with microcephaly infected with ZIKV born to infected mothers indicate a possible role of the virus in odontogenesis.
Authors: Isabella Fernandes Carvalho; Louise Cristina Pereira Freitas; Phillipe Nogueira Barbosa Alencar; Maria Cláudia de Freitas Lima; Daniel de Sá Cavalcante; José Luciano Pimenta Couto; Paulo Tarcio Aded Silva; Dhaniel Anderson Olímpio Barbosa; Ellaine Dóris Fernandes Carvalho; Fabrício Bitu Sousa Journal: J Dent Res Dent Clin Dent Prospects Date: 2022-05-29