Literature DB >> 31775

Generation of free radicals from phenazine methosulfate in Trypanosoma cruzi epimastigotes.

R Docampo, F S Cruz, R P Muniz, D M Esquivel, M E de Vasconcellos.   

Abstract

A significant growth inhibition of Trypanosoma cruzi epimastigotes by phenazine methosulfate (PMS) was observed in Warren's medium. This toxic activity could be related to the following parameters: a) formation of phenazinium free radical, b) generation of superoxide anion in intact cells incubated with PMS, and c) PMS also increased significantly the rate of O2- generation in epimastigotes mitochondrial and microsomal fractions using NADH as electron donor.

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Year:  1978        PMID： 31775

Source DB:  PubMed          Journal:  Acta Trop        ISSN： 0001-706X            Impact factor:   3.112


  3 in total

1.  Destruction of intracellular Trypanosoma cruzi after treatment of infected macrophages with cationic electron carriers.

Authors:  M J Alves; M Rabinovitch
Journal:  Infect Immun       Date:  1983-01       Impact factor: 3.441

2.  A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi.

Authors:  Bruno Kilunga Kubata; Zakayi Kabututu; Tomoyoshi Nozaki; Craig J Munday; Shunichi Fukuzumi; Kei Ohkubo; Michael Lazarus; Toshihiko Maruyama; Samuel K Martin; Michael Duszenko; Yoshihiro Urade
Journal:  J Exp Med       Date:  2002-11-04       Impact factor: 14.307

3.  Destruction of Leishmania mexicana amazonensis amastigotes within macrophages in culture by phenazine methosulfate and other electron carriers.

Authors:  M Rabinovitch; J P Dedet; A Ryter; R Robineaux; G Topper; E Brunet
Journal:  J Exp Med       Date:  1982-02-01       Impact factor: 14.307
  3 in total

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