Literature DB >> 3177479

Fragile-X mutation proposed to block complete reactivation in females of an inactive X chromosome.

C D Laird1.   

Abstract

I discuss two aspects of my proposal that fra(X) chromosomes exist in two states, imprinted and non-imprinted: why do males not imprint the fra(X); does the "Sherman paradox" rule out my proposal?

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Mesh：

Year:  1988        PMID： 3177479     DOI： 10.1002/ajmg.1320300171

Source DB:  PubMed          Journal:  Am J Med Genet        ISSN： 0148-7299


  4 in total

1.  Population genetics of the fragile-X syndrome: multiallelic model for the FMR1 locus.

Authors:  N E Morton; J N Macpherson
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205

2.  Fragile X expression and X inactivation. I. The expression of the fragile site at Xq27.3 is not suppressed on inactive X chromosomes separated from the active homologue.

Authors:  D Wöhrle; J P Fryns; P Steinbach
Journal:  Hum Genet       Date:  1990-10       Impact factor: 4.132

3.  Fragile X expression and X inactivation. II. The fragile site at Xq27.3 has a basic function in the pathogenesis of fragile X-linked mental retardation.

Authors:  D Wöhrle; P Steinbach
Journal:  Hum Genet       Date:  1991-08       Impact factor: 4.132

4.  Molecular analysis of mutations in the gene FMR-1 segregating in fragile X families.

Authors:  P Steinbach; D Wöhrle; G Tariverdian; I Kennerknecht; G Barbi; H Edlinger; H Enders; M Götz-Sothmann; H Heilbronner; D Hosenfeld
Journal:  Hum Genet       Date:  1993-11       Impact factor: 4.132
  4 in total

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