Literature DB >> 3177471

Pulsed-field gel mapping studies in the vicinity of the fragile site at Xq27.3.

M Patterson1, M Bell, C Schwartz, K Davies.   

Abstract

Physical mapping strategies are being employed for an analysis of the fragile X site region. Deletion breakpoints which may be close to the fragile site appear to be at a distance of at least several hundred kb from the nearest DNA probes. Further evidence is found for physical linkage between St14 (DXS52), DX13 (DXS15) and MN12 (DXS33). The data indicate differences in CG content and/or methylation levels between the distal and proximal sides of the fragile site.

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Year:  1988        PMID： 3177471     DOI： 10.1002/ajmg.1320300159

Source DB:  PubMed          Journal:  Am J Med Genet        ISSN： 0148-7299


  8 in total

1.  Physical and genetic mapping of polymorphic loci in Xq28 (DXS15, DXS52, and DXS134): analysis of a cosmid clone and a yeast artificial chromosome.

Authors:  R Feil; G Palmieri; M d'Urso; R Heilig; I Oberlé; J L Mandel
Journal:  Am J Hum Genet       Date:  1990-04       Impact factor: 11.025

2.  Physical mapping of DXS134 close to the DXS52 locus.

Authors:  M V Bell; M N Patterson; H R Dorkins; K E Davies
Journal:  Hum Genet       Date:  1989-04       Impact factor: 4.132

3.  An intronic region within the human factor VIII gene is duplicated within Xq28 and is homologous to the polymorphic locus DXS115 (767).

Authors:  M Patterson; J Gitschier; J Bloomfield; M Bell; H Dorkins; U Froster-Iskenius; S Sommer; J Sobell; D Schaid; S Thibodeau
Journal:  Am J Hum Genet       Date:  1989-05       Impact factor: 11.025

4.  Fine structure mapping of the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene region of the human X chromosome (Xq26).

Authors:  J A Nicklas; T C Hunter; J P O'Neill; R J Albertini
Journal:  Am J Hum Genet       Date:  1991-08       Impact factor: 11.025

5.  A contiguous, 3-Mb physical map of Xq28 extending from the colorblindness locus to DXS15.

Authors:  S Kenwrick; J Gitschier
Journal:  Am J Hum Genet       Date:  1989-12       Impact factor: 11.025

6.  New polymorphisms at the DXS98 locus and confirmation of its location proximal to FRAXA by in situ hybridization.

Authors:  R E Schnur; S A Ledbetter; D H Ledbetter; D E Merry; R L Nussbaum
Journal:  Am J Hum Genet       Date:  1989-02       Impact factor: 11.025

7.  Mapping of human chromosome Xq28 by two-color fluorescence in situ hybridization of DNA sequences to interphase cell nuclei.

Authors:  B J Trask; H Massa; S Kenwrick; J Gitschier
Journal:  Am J Hum Genet       Date:  1991-01       Impact factor: 11.025

8.  Mapping of the locus for X-linked cardioskeletal myopathy with neutropenia and abnormal mitochondria (Barth syndrome) to Xq28.

Authors:  P A Bolhuis; G W Hensels; T J Hulsebos; F Baas; P G Barth
Journal:  Am J Hum Genet       Date:  1991-03       Impact factor: 11.025
  8 in total

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