| Literature DB >> 31773957 |
Lloyd C Murfin1, Maria Weber1,2, Sang Jun Park3, Won Tae Kim3, Carlos M Lopez-Alled1,2, Claire L McMullin1, Fabienne Pradaux-Caggiano1, Catherine L Lyall4, Gabriele Kociok-Köhn4, Jannis Wenk2,5, Steven D Bull1,2, Juyoung Yoon6, Hwan Myung Kim3, Tony D James1,2, Simon E Lewis1,2.
Abstract
Two-photon fluorescence microscopy has become an indispensable technique for cellular imaging. Whereas most two-photon fluorescent probes rely on well-known fluorophores, here we report a new fluorophore for bioimaging, namely azulene. A chemodosimeter, comprising a boronate ester receptor motif conjugated to an appropriately substituted azulene, is shown to be an effective two-photon fluorescent probe for reactive oxygen species, showing good cell penetration, high selectivity for peroxynitrite, no cytotoxicity, and excellent photostability.Entities:
Mesh：
Substances：
Year: 2019 PMID： 31773957 PMCID： PMC6909233 DOI： 10.1021/jacs.9b09813
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419