| Literature DB >> 31773256 |
Maria Strauß1, Andreas Reif2, Christine Ulke1, Madlen Paucke1, Christian Sander1,3, Ulrich Hegerl1,2,3, Heike Weber2,4, Julia Heupel4, Juliane Kopf2, Sarah Kittel-Schneider5,6.
Abstract
We investigated whether baseline brain arousal instability during resting state EEG, using the Vigilance Algorithm Leipzig (VIGALL 2.1), can predict response to methylphenidate therapy in adult ADHD patients. An arousal stability score of the EEGs of 28 adult ADHD patients was calculated quantifying the extent of arousal decline. In logistic regression analysis, arousal stability score predicted response to MPH [odds ratio 1.28 (95% CI 1.0-1.65); p = 0.027]. In this pilot study, we demonstrated that arousal stability at baseline predicted methylphenidate treatment response, indicating that less stable arousal regulation during a 15-min EEG at rest increases the chance of treatment response.Entities:
Keywords: ADHD; EEG; Stimulants; Treatment response biomarker; Vigilance
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Year: 2019 PMID： 31773256 DOI： 10.1007/s00406-019-01085-y
Source DB: PubMed Journal: Eur Arch Psychiatry Clin Neurosci ISSN： 0940-1334 Impact factor: 5.270