Lynn Meurs1, Felix S Lempp2, Norman Lippmann3, Henning Trawinski2, Arne C Rodloff3, Matthias Eckardt4, Anja Klingeberg4, Tim Eckmanns4, Jan Walter4, Christoph Lübbert5. 1. European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control, Gustav III:s Boulevard 40, 16973, Solna, Sweden; Robert Koch Institute, Seestraße 10, 13353, Berlin, Germany. Electronic address: lynn.meurs@gmail.com. 2. Division of Infectious Diseases and Tropical Medicine, Department of Gastroenterology, Leipzig University Hospital, Liebigstraße 20, 04103, Leipzig, Germany. 3. Interdisciplinary Centre for Infectious Diseases, Leipzig University Hospital, Liebigstraße 20, 04103, Leipzig, Germany. 4. Robert Koch Institute, Seestraße 10, 13353, Berlin, Germany. 5. Division of Infectious Diseases and Tropical Medicine, Department of Gastroenterology, Leipzig University Hospital, Liebigstraße 20, 04103, Leipzig, Germany; Interdisciplinary Centre for Infectious Diseases, Leipzig University Hospital, Liebigstraße 20, 04103, Leipzig, Germany.
Abstract
BACKGROUND: Intercontinental travel contributes to the spread of extended-spectrum beta-lactamase producing Enterobacterales (ESBL-PE). We assessed risk factors for intestinal ESBL-PE colonization in people travelling to low and middle income countries in the tropics and subtropics to better understand how travel affects ESBL-PE spread. METHOD: This prospective cohort study in travellers attending a travel clinic in Leipzig, Germany was conducted in 2016-2017. Information on risk factors related to travel, symptoms, antibiotic use, health care usage, accommodation, destination, diet and hygiene was collected by questionnaire after travel. Stools were phenotypically tested for ESBL-PE before and after travel. Risk factors for ESBL-PE colonization were identified using logistic regression. RESULTS: Of the 230 travellers that were ESBL-PE negative before travelling, 23% (n = 53) travellers returned positive. Multivariable analyses showed that age, type of accommodation and travelling to Asia were associated with ESBL-PE colonization. CONCLUSIONS: Given that a considerable amount of travellers returned with ESBL-PE, we recommend raising awareness in returning high-risk travellers, e.g. those returning from high-risk areas. They should be aware that they may carry antimicrobial-resistant bacteria after travel, and how they can prevent its spread. The role of the type of accommodation as a factor favouring intestinal colonization with ESBL-PE requires further investigation.
BACKGROUND: Intercontinental travel contributes to the spread of extended-spectrum beta-lactamase producing Enterobacterales (ESBL-PE). We assessed risk factors for intestinal ESBL-PE colonization in people travelling to low and middle income countries in the tropics and subtropics to better understand how travel affects ESBL-PE spread. METHOD: This prospective cohort study in travellers attending a travel clinic in Leipzig, Germany was conducted in 2016-2017. Information on risk factors related to travel, symptoms, antibiotic use, health care usage, accommodation, destination, diet and hygiene was collected by questionnaire after travel. Stools were phenotypically tested for ESBL-PE before and after travel. Risk factors for ESBL-PE colonization were identified using logistic regression. RESULTS: Of the 230 travellers that were ESBL-PE negative before travelling, 23% (n = 53) travellers returned positive. Multivariable analyses showed that age, type of accommodation and travelling to Asia were associated with ESBL-PE colonization. CONCLUSIONS: Given that a considerable amount of travellers returned with ESBL-PE, we recommend raising awareness in returning high-risk travellers, e.g. those returning from high-risk areas. They should be aware that they may carry antimicrobial-resistant bacteria after travel, and how they can prevent its spread. The role of the type of accommodation as a factor favouring intestinal colonization with ESBL-PE requires further investigation.
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