| Literature DB >> 31770087 |
Yawara Eguchi1, Toru Toyoguchi2, Kazuhide Inage3, Kazuki Fujimoto3, Sumihisa Orita3, Miyako Suzuki3, Hirohito Kanamoto3, Koki Abe3, Masaki Norimoto3, Tomotaka Umimura3, Masao Koda3, Takeo Furuya3, Yasuchika Aoki4, Junichi Nakamura3, Tsutomu Akazawa5, Kazuhisa Takahashi3, Seiji Ohtori3.
Abstract
The aim of this study was to determine whether advanced glycation end products (AGEs) revealed by skin autofluorescence (SAF), serum and urine pentosidine level, and serum homocysteine level can serve as a biomarker for sarcopenia in older women. The participants were 70 elderly women. The AGEs pentosidine, homocysteine, and SAF were measured as aging markers. This study shows that among the biomarkers for aging, serum pentosidine correlates with a loss of appendicular lean mass and can serve as a biomarker for sarcopenia. Moreover, SAF and homocysteine values exhibited a positive correlation with age and correlated with each other.Abbreviations: AGEs: advanced glycation end products; BIA: bioelectrical impedance analyzer; BMD: bone mineral density; DLS: degenerative lumbar scoliosis; DXA: dual-energy X-ray absorptiometry; ELISA: enzyme-linked immunoassay; HHcy: hyperhomocysteinemia; RIA: radioimmunoassay; SAF: skin autofluorescence; SMI: skeletal muscle mass index; T2DM: type 2 diabetes patients.Entities:
Keywords: Advanced glycation end-products; pentosidine; sarcopenia
Year: 2019 PMID： 31770087 DOI： 10.1080/08952841.2019.1697161
Source DB: PubMed Journal: J Women Aging ISSN： 0895-2841