Literature DB >> 31769940

Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop

Rong Tian1, Wilson S. Colucci2, Zoltan Arany3, Markus M. Bachschmid2, Scott W. Ballinger4, Sihem Boudina5, James E. Bruce6, David W. Busija7, Sergey Dikalov8, Gerald W. Dorn9, Zorina S. Galis10, Roberta A. Gottlieb11, Daniel P. Kelly3, Richard N. Kitsis12, Mark J. Kohr13, Daniel Levy10, E. Douglas Lewandowski14, Joseph M. McClung15, Daria Mochly-Rosen16, Kevin D. O'Brien17, Brian O'Rourke18, Joon-Young Park19, Peipei Ping20, Michael N. Sack10, Shey-Shing Sheu21, Yang Shi10, Sruti Shiva22, Douglas C. Wallace23, Robert G. Weiss18, Hilary J. Vernon24, Renee Wong10, Lisa Schwartz Longacre10.   

Abstract

Mitochondria have emerged as a central factor in the pathogenesis and progression of heart failure, and other cardiovascular diseases, as well, but no therapies are available to treat mitochondrial dysfunction. The National Heart, Lung, and Blood Institute convened a group of leading experts in heart failure, cardiovascular diseases, and mitochondria research in August 2018. These experts reviewed the current state of science and identified key gaps and opportunities in basic, translational, and clinical research focusing on the potential of mitochondria-based therapeutic strategies in heart failure. The workshop provided short- and long-term recommendations for moving the field toward clinical strategies for the prevention and treatment of heart failure and cardiovascular diseases by using mitochondria-based approaches.
© 2019 American Heart Association, Inc.

Entities:  

Keywords:  cardiovascular diseases; heart failure; mitochondria

Mesh：

Year:  2019        PMID： 31769940      PMCID： PMC6880654          DOI： 10.1161/CIRCULATIONAHA.119.040551

Source DB:  PubMed          Journal:  Circulation        ISSN： 0009-7322            Impact factor:   29.690


  69 in total

1.  Effects of purifying and adaptive selection on regional variation in human mtDNA.

Authors:  Eduardo Ruiz-Pesini; Dan Mishmar; Martin Brandon; Vincent Procaccio; Douglas C Wallace
Journal:  Science       Date:  2004-01-09       Impact factor: 47.728

2.  Vitamin E supplementation and cardiovascular events in high-risk patients.

Authors:  S Yusuf; G Dagenais; J Pogue; J Bosch; P Sleight
Journal:  N Engl J Med       Date:  2000-01-20       Impact factor: 91.245

Review 3.  The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: a complementary concept to Mendelian genetics.

Authors:  David M Krzywanski; Douglas R Moellering; Jessica L Fetterman; Kimberly J Dunham-Snary; Melissa J Sammy; Scott W Ballinger
Journal:  Lab Invest       Date:  2011-06-06       Impact factor: 5.662

4.  Sex differences in the phosphorylation of mitochondrial proteins result in reduced production of reactive oxygen species and cardioprotection in females.

Authors:  Claudia J Lagranha; Anne Deschamps; Angel Aponte; Charles Steenbergen; Elizabeth Murphy
Journal:  Circ Res       Date:  2010-04-22       Impact factor: 17.367

5.  Reduction of early reperfusion injury with the mitochondria-targeting peptide bendavia.

Authors:  David A Brown; Sharon L Hale; Christopher P Baines; Carlos L del Rio; Robert L Hamlin; Yukie Yueyama; Anusak Kijtawornrat; Steve T Yeh; Chad R Frasier; Luke M Stewart; Fatiha Moukdar; Saame Raza Shaikh; Kelsey H Fisher-Wellman; P Darrell Neufer; Robert A Kloner
Journal:  J Cardiovasc Pharmacol Ther       Date:  2013-11-28       Impact factor: 2.457

6.  Enhanced Redox State and Efficiency of Glucose Oxidation With miR Based Suppression of Maladaptive NADPH-Dependent Malic Enzyme 1 Expression in Hypertrophied Hearts.

Authors:  Ryan Lahey; Andrew N Carley; Xuerong Wang; Carley E Glass; Kevin D Accola; Scott Silvestry; J Michael O'Donnell; E Douglas Lewandowski
Journal:  Circ Res       Date:  2018-01-31       Impact factor: 17.367

7.  Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy.

Authors:  Delyth Graham; Ngan N Huynh; Carlene A Hamilton; Elisabeth Beattie; Robin A J Smith; Helena M Cochemé; Michael P Murphy; Anna F Dominiczak
Journal:  Hypertension       Date:  2009-07-06       Impact factor: 10.190

8.  Telomerase reverse transcriptase protects against angiotensin II-induced microvascular endothelial dysfunction.

Authors:  Karima Ait-Aissa; Andrew O Kadlec; Joseph Hockenberry; David D Gutterman; Andreas M Beyer
Journal:  Am J Physiol Heart Circ Physiol       Date:  2017-12-22       Impact factor: 5.125

9.  Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation.

Authors:  Oswaldo A Lozoya; Inmaculada Martinez-Reyes; Tianyuan Wang; Dagoberto Grenet; Pierre Bushel; Jianying Li; Navdeep Chandel; Richard P Woychik; Janine H Santos
Journal:  PLoS Biol       Date:  2018-04-18       Impact factor: 8.029

Review 10.  The Bioenergetic Health Index: a new concept in mitochondrial translational research.

Authors:  Balu K Chacko; Philip A Kramer; Saranya Ravi; Gloria A Benavides; Tanecia Mitchell; Brian P Dranka; David Ferrick; Ashwani K Singal; Scott W Ballinger; Shannon M Bailey; Robert W Hardy; Jianhua Zhang; Degui Zhi; Victor M Darley-Usmar
Journal:  Clin Sci (Lond)       Date:  2014-09       Impact factor: 6.124
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  37 in total

Review 1.  Markers of Immune Function in Heart Transplantation: Implications for Immunosuppression and Screening for Rejection.

Authors:  David X Zhuo; Katie Ginder; E Ashley Hardin
Journal:  Curr Heart Fail Rep       Date:  2021-01-05

2.  Elevated MCU Expression by CaMKIIδB Limits Pathological Cardiac Remodeling.

Authors:  Pei Wang; Shangcheng Xu; Jiqian Xu; Yanguo Xin; Yan Lu; Huiliang Zhang; Bo Zhou; Haodong Xu; Shey-Shing Sheu; Rong Tian; Wang Wang
Journal:  Circulation       Date:  2022-02-15       Impact factor: 29.690

3.  SGLT2 inhibitors: further evidence for heart failure with preserved ejection fraction as a metabolic disease?

Authors:  Justin B Echouffo-Tcheugui; Sabra C Lewsey; Robert G Weiss
Journal:  J Clin Invest       Date:  2021-12-01       Impact factor: 14.808

4.  MicroRNA-210 Controls Mitochondrial Metabolism and Protects Heart Function in Myocardial Infarction.

Authors:  Rui Song; Chiranjib Dasgupta; Cassidy Mulder; Lubo Zhang
Journal:  Circulation       Date:  2022-03-17       Impact factor: 29.690

5.  Increasing mitochondrial ATP synthesis with butyrate normalizes ADP and contractile function in metabolic heart disease.

Authors:  Marcello Panagia; Huamei He; Tomas Baka; David R Pimentel; Dominique Croteau; Markus M Bachschmid; James A Balschi; Wilson S Colucci; Ivan Luptak
Journal:  NMR Biomed       Date:  2020-02-17       Impact factor: 4.044

Review 6.  Cardiac Energy Metabolism in Heart Failure.

Authors:  Gary D Lopaschuk; Qutuba G Karwi; Rong Tian; Adam R Wende; E Dale Abel
Journal:  Circ Res       Date:  2021-05-13       Impact factor: 17.367

7.  ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ.

Authors:  Mario G Pavez-Giani; Pablo I Sánchez-Aguilera; Nils Bomer; Shigeki Miyamoto; Harmen G Booij; Paula Giraldo; Silke U Oberdorf-Maass; Kirsten T Nijholt; Salva R Yurista; Hendrik Milting; Peter van der Meer; Rudolf A de Boer; Joan Heller Brown; Herman W H Sillje; B Daan Westenbrink
Journal:  Int J Mol Sci       Date:  2021-04-23       Impact factor: 5.923

8.  Cardiomyopathic mutations in essential light chain reveal mechanisms regulating the super relaxed state of myosin.

Authors:  Yoel H Sitbon; Francisca Diaz; Katarzyna Kazmierczak; Jingsheng Liang; Medhi Wangpaichitr; Danuta Szczesna-Cordary
Journal:  J Gen Physiol       Date:  2021-05-20       Impact factor: 4.086

9.  Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure.

Authors:  Gizem Keceli; Ashish Gupta; Joevin Sourdon; Refaat Gabr; Michael Schär; Swati Dey; Carlo G Tocchetti; Annina Stuber; Jacopo Agrimi; Yi Zhang; Michelle Leppo; Charles Steenbergen; Shenghan Lai; Lisa R Yanek; Brian O'Rourke; Gary Gerstenblith; Paul A Bottomley; Yibin Wang; Nazareno Paolocci; Robert G Weiss
Journal:  Circ Res       Date:  2022-02-03       Impact factor: 17.367

10.  Salt Transiently Inhibits Mitochondrial Energetics in Mononuclear Phagocytes.

Authors:  Hendrik Bartolomaeus; Patrick Neubert; Markus Kleinewietfeld; Jonathan Jantsch; Stefan Kempa; Dominik N Müller; Sabrina Geisberger; Ralf Willebrand; Christin Zasada; Thomas Bartolomaeus; Victoria McParland; Dries Swinnen; Anneleen Geuzens; András Maifeld; Luka Krampert; Marion Vogl; Anja Mähler; Nicola Wilck; Lajos Markó; Ekin Tilic; Sofia K Forslund; Katrina J Binger; Johannes Stegbauer; Ralf Dechend
Journal:  Circulation       Date:  2021-04-28       Impact factor: 29.690
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