Literature DB >> 31769676

ROBOKOP KG and KGB: Integrated Knowledge Graphs from Federated Sources.

Chris Bizon1, Steven Cox1, James Balhoff1, Yaphet Kebede1, Patrick Wang2, Kenneth Morton2, Karamarie Fecho1, Alexander Tropsha3.   

Abstract

A proliferation of data sources has led to the notional existence of an implicit Knowledge Graph (KG) that contains vast amounts of biological knowledge contributed by distributed Application Programming Interfaces (APIs). However, challenges arise when integrating data across multiple APIs due to incompatible semantic types, identifier schemes, and data formats. We present ROBOKOP KG ( http://robokopkg.renci.org ), which is a KG that was initially built to support the open biomedical question-answering application, ROBOKOP (Reasoning Over Biomedical Objects linked in Knowledge-Oriented Pathways) ( http://robokop.renci.org ). Additionally, we present the ROBOKOP Knowledge Graph Builder (KGB), which constructs the KG and provides an extensible framework to handle graph query over and integration of federated data sources.

Mesh:

Year:  2019        PMID: 31769676     DOI: 10.1021/acs.jcim.9b00683

Source DB:  PubMed          Journal:  J Chem Inf Model        ISSN: 1549-9596            Impact factor:   4.956


  7 in total

Review 1.  Knowledge-based approaches to drug discovery for rare diseases.

Authors:  Vinicius M Alves; Daniel Korn; Vera Pervitsky; Andrew Thieme; Stephen J Capuzzi; Nancy Baker; Rada Chirkova; Sean Ekins; Eugene N Muratov; Anthony Hickey; Alexander Tropsha
Journal:  Drug Discov Today       Date:  2021-10-27       Impact factor: 8.369

2.  COVID-KOP: Integrating Emerging COVID-19 Data with the ROBOKOP Database.

Authors:  Daniel Korn; Tesia Bobrowski; Michael Li; Yaphet Kebede; Patrick Wang; Phillips Owen; Gaurav Vaidya; Eugene Muratov; Rada Chirkova; Chris Bizon; Alexander Tropsha
Journal:  ChemRxiv       Date:  2020-06-18

3.  Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro.

Authors:  Tesia Bobrowski; Lu Chen; Richard T Eastman; Zina Itkin; Paul Shinn; Catherine Chen; Hui Guo; Wei Zheng; Sam Michael; Anton Simeonov; Matthew D Hall; Alexey V Zakharov; Eugene N Muratov
Journal:  bioRxiv       Date:  2020-06-30

4.  Synergistic and Antagonistic Drug Combinations against SARS-CoV-2.

Authors:  Tesia Bobrowski; Lu Chen; Richard T Eastman; Zina Itkin; Paul Shinn; Catherine Z Chen; Hui Guo; Wei Zheng; Sam Michael; Anton Simeonov; Matthew D Hall; Alexey V Zakharov; Eugene N Muratov
Journal:  Mol Ther       Date:  2020-12-15       Impact factor: 11.454

5.  COVID-19 Knowledge Extractor (COKE): A Tool and a Web Portal to Extract Drug - Target Protein Associations from the CORD-19 Corpus of Scientific Publications on COVID-19.

Authors:  Daniel Korn; Vera Pervitsky; Tesia Bobrowski; Vinicius Alves; Charles Schmitt; Cristopher Bizon; Nancy Baker; Rada Chirkova; Artem Cherkasov; Eugene Muratov; Alexander Tropsha
Journal:  ChemRxiv       Date:  2020-11-26

6.  Visualization Environment for Federated Knowledge Graphs: Development of an Interactive Biomedical Query Language and Web Application Interface.

Authors:  Steven Cox; Stanley C Ahalt; James Balhoff; Chris Bizon; Karamarie Fecho; Yaphet Kebede; Kenneth Morton; Alexander Tropsha; Patrick Wang; Hao Xu
Journal:  JMIR Med Inform       Date:  2020-11-23

7.  Application of MCAT questions as a testing tool and evaluation metric for knowledge graph-based reasoning systems.

Authors:  Karamarie Fecho; James Balhoff; Chris Bizon; William E Byrd; Sui Hang; David Koslicki; Stefano E Rensi; Patrick L Schmitt; Mathias J Wawer; Mark Williams; Stanley C Ahalt
Journal:  Clin Transl Sci       Date:  2021-04-09       Impact factor: 4.689

  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.