| Literature DB >> 31768855 |
E V Kryukova1, A S Potapenko2, T V Andreeva2, I A Ivanov2, V V Ryabinin2, R H Ziganshin2, V G Starkov2, N M Ayvazyan3, V I Tsetlin2, Yu N Utkin2.
Abstract
Four dimeric disintegrins were isolated from the venom of the steppe viper V. ursinii using liquid chromatography. Disintegrins prevented adhesion of MCF7 cells to fibronectin, which indicates their interaction with integrin receptors of the αVβ1 type. According to mass spectrometry data, the molar masses of disintegrins are about 14 kDa. The method of peptide mapping established the structure of a new heterodimeric disintegrin weighing 13 995.5 Da and shows that it belongs to the class of RGD/KGD-containing disintegrins.Entities:
Mesh：
Substances：
Year: 2019 PMID： 31768855 DOI： 10.1134/S1607672919050132
Source DB: PubMed Journal: Dokl Biochem Biophys ISSN： 1607-6729 Impact factor: 0.788