Literature DB >> 31768851

Potassium Salt of Fullerenylpenta-N-Dihydroxytyrosine Effects on Type 2 Diabetes Mellitus Therapeutic Targets.

Yu V Soldatova1,2, R A Kotelnikova3, A V Zhilenkov3, I I Faingold3,4, P A Troshin3,5, M A Kozlova4, D A Areshidze3,4, S M Aldoshin3.   

Abstract

It was shown for the first time that pentaamino acid derivative of fullerene C60 (potassium salt of fullerenylpenta-N-dihydroxytyrosine) affects three targets of type 2 diabetes mellitus. It competitively inhibits the enzymes aldose reductase and sorbitol dehydrogenase and also has an antiglycation effect on bovine serum albumin. The inhibition constants for these enzymes were calculated.

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Year:  2019        PMID： 31768851     DOI： 10.1134/S1607672919050089

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  5 in total

1.  Protective effect of magnesium-25 carrying porphyrin-fullerene nanoparticles on degeneration of dorsal root ganglion neurons and motor function in experimental diabetic neuropathy.

Authors:  Asieh Hosseini; Mohammad Abdollahi; Gholamreza Hassanzadeh; Mahdi Rezayat; Shokoufeh Hassani; Nazila Pourkhalili; Kaveh Tabrizian; Tina Khorshidahmad; Cordian Beyer; Mohammad Sharifzadeh
Journal:  Basic Clin Pharmacol Toxicol       Date:  2011-07-12       Impact factor: 4.080

2.  Strong inhibition of the polyol pathway diverts glucose flux to protein glycation leading to rapid establishment of secondary complications in diabetes mellitus.

Authors:  Ashwini D Jagdale; Laxman N Bavkar; Tanaji A More; Madhav M Joglekar; Akalpita U Arvindekar
Journal:  J Diabetes Complications       Date:  2016-01-06       Impact factor: 2.852

3.  Aldose reductase inhibition of a saponin-rich fraction and new furostanol saponin derivatives from Balanites aegyptiaca.

Authors:  Amira Abdel Motaal; Hesham El-Askary; Sara Crockett; Olaf Kunert; Basma Sakr; Sherif Shaker; Alice Grigore; Radu Albulescu; Rudolf Bauer
Journal:  Phytomedicine       Date:  2015-06-20       Impact factor: 5.340

4.  Redox imbalance stress in diabetes mellitus: Role of the polyol pathway.

Authors:  Liang-Jun Yan
Journal:  Animal Model Exp Med       Date:  2018-04-19

Review 5.  Polyphenols with antiglycation activity and mechanisms of action: A review of recent findings.

Authors:  Wan-Ju Yeh; Shih-Min Hsia; Wei-Hwa Lee; Chi-Hao Wu
Journal:  J Food Drug Anal       Date:  2016-12-05       Impact factor: 6.157
  5 in total
  1 in total

1.  How fullerene derivatives (FDs) act on therapeutically important targets associated with diabetic diseases.

Authors:  Natalja Fjodorova; Marjana Novič; Katja Venko; Viktor Drgan; Bakhtiyor Rasulev; Melek Türker Saçan; Safiye Sağ Erdem; Gulcin Tugcu; Alla P Toropova; Andrey A Toropov
Journal:  Comput Struct Biotechnol J       Date:  2022-02-12       Impact factor: 7.271
  1 in total

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