Literature DB >> 31768847

Sigma-1 Receptor Agonist Amitriptyline Inhibits Store-Dependent Ca2+ Entry in Macrophages.

Z I Krutetskaya1, L S Milenina2, V G Antonov2, A D Nozdrachev3,4.   

Abstract

Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist-tricyclic antidepressant amitriptyline-significantly inhibits store-dependent Ca2+ entry, induced by endoplasmic Ca2+-ATPase inhibitors thapsigargin and cyclopiazonic acid, in rat peritoneal macrophages. The results suggest a possible involvement of sigma-1 receptors in the regulation of store-dependent Ca2+ entry in macrophages.

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Year:  2019        PMID： 31768847     DOI： 10.1134/S1607672919050041

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  14 in total

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Review 4.  Store-Operated Calcium Entry: An Historical Overview.

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6.  [THE EFFECT OF EPOXYGENASE INHIBITORS ON Ca(2+)-RESPONSES INDUCED BY GLUTOXIM AND MOLIXAN IN MACROPHAGES].

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7.  Inhibition of the cardiac L-type calcium channel current by antidepressant drugs.

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Review 8.  The Role of Sigma-1 Receptor, an Intracellular Chaperone in Neurodegenerative Diseases.

Authors:  Botond Penke; Livia Fulop; Maria Szucs; Ede Frecska
Journal:  Curr Neuropharmacol       Date:  2018       Impact factor: 7.363

9.  Pharmacology and therapeutic potential of sigma(1) receptor ligands.

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Journal:  Curr Neuropharmacol       Date:  2008-12       Impact factor: 7.363

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  2 in total

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Review 2.  Emerging Benefits: Pathophysiological Functions and Target Drugs of the Sigma-1 Receptor in Neurodegenerative Diseases.

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  2 in total

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