Bamini Gopinath1, Gerald Liew2, Joshua R Lewis3,4,5, Nicola P Bondonno6, Catherine P Bondonno4,5, George Burlutsky2, Jonathan M Hodgson4,5, Paul Mitchell2. 1. Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, Westmead Hospital, University of Sydney, Westmead, NSW, 2145, Australia. bamini.gopinath@sydney.edu.au. 2. Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, Westmead Hospital, University of Sydney, Westmead, NSW, 2145, Australia. 3. Centre for Kidney Research, Westmead Institute for Medical Research, School of Public Health, University of Sydney, Westmead, NSW, Australia. 4. School of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia. 5. Medical School, University of Western Australia, Perth, WA, Australia. 6. School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia.
Abstract
PURPOSE: In this study, we assessed whether there are independent associations between dietary total flavonoid intake and major flavonoid classes with retinal arteriolar and venular calibre. METHODS: Blue Mountains Eye Study participants aged 49+ years who had complete data on diet and retinal vessel measures were analysed (n = 2821). Dietary intake was assessed using a semi-quantitative Food-Frequency Questionnaire (FFQ). Flavonoid content of foods in the FFQ was estimated using the US Department of Agriculture Flavonoid, Isoflavone and Proanthocyanidin databases. Fundus photographs were taken and retinal vascular calibre was measured using validated computer-assisted techniques. The associations of intake of dietary flavonoids with retinal vessel calibre were examined in linear regression models and general linear model. RESULTS: The highest quartile of intake was compared with the lowest quartile using multivariable-adjustment models. Participants with the highest proanthocyanidin intake had narrower retinal venules (223.9 ± 0.62 versus 226.5 ± 0.63, respectively; Ptrend = 0.01); and the highest isoflavone intake was associated with wider retinal arterioles (188.1 ± 0.55 versus 186.3 ± 0.56, respectively; Ptrend = 0.01). The highest apple/pear consumption (a dietary source of catechin) was associated with narrower retinal venules (223.8 ± 0.57 versus 226.1 ± 0.52; Ptrend = 0.01) and wider retinal arterioles (187.9 ± 0.51 versus 186.2 ± 0.51; Ptrend = 0.02). Further, participants who were in the highest versus lowest quartile of chocolate consumption had ~ 2.1 μm narrower retinal venules (multivariable-adjusted P = 0.03). CONCLUSIONS: This study shows that higher intakes of specific flavonoid subclasses are associated with a favourable retinal microvascular profile. Greater consumption of flavonoid-rich apples/pears and chocolate was also associated with beneficial variations in retinal vascular calibre.
PURPOSE: In this study, we assessed whether there are independent associations between dietary total flavonoid intake and major flavonoid classes with retinal arteriolar and venular calibre. METHODS: Blue Mountains Eye Study participants aged 49+ years who had complete data on diet and retinal vessel measures were analysed (n = 2821). Dietary intake was assessed using a semi-quantitative Food-Frequency Questionnaire (FFQ). Flavonoid content of foods in the FFQ was estimated using the US Department of Agriculture Flavonoid, Isoflavone and Proanthocyanidin databases. Fundus photographs were taken and retinal vascular calibre was measured using validated computer-assisted techniques. The associations of intake of dietary flavonoids with retinal vessel calibre were examined in linear regression models and general linear model. RESULTS: The highest quartile of intake was compared with the lowest quartile using multivariable-adjustment models. Participants with the highest proanthocyanidin intake had narrower retinal venules (223.9 ± 0.62 versus 226.5 ± 0.63, respectively; Ptrend = 0.01); and the highest isoflavone intake was associated with wider retinal arterioles (188.1 ± 0.55 versus 186.3 ± 0.56, respectively; Ptrend = 0.01). The highest apple/pear consumption (a dietary source of catechin) was associated with narrower retinal venules (223.8 ± 0.57 versus 226.1 ± 0.52; Ptrend = 0.01) and wider retinal arterioles (187.9 ± 0.51 versus 186.2 ± 0.51; Ptrend = 0.02). Further, participants who were in the highest versus lowest quartile of chocolate consumption had ~ 2.1 μm narrower retinal venules (multivariable-adjusted P = 0.03). CONCLUSIONS: This study shows that higher intakes of specific flavonoid subclasses are associated with a favourable retinal microvascular profile. Greater consumption of flavonoid-rich apples/pears and chocolate was also associated with beneficial variations in retinal vascular calibre.
Entities:
Keywords:
Blue Mountains Eye Study; Flavonoids; Retinal vascular calibre
Authors: Hagen Schroeter; Christian Heiss; Jan Balzer; Petra Kleinbongard; Carl L Keen; Norman K Hollenberg; Helmut Sies; Catherine Kwik-Uribe; Harold H Schmitz; Malte Kelm Journal: Proc Natl Acad Sci U S A Date: 2006-01-17 Impact factor: 11.205
Authors: Oana M Dumitrascu; Bart M Demaerschalk; Cristina Valencia Sanchez; Diana Almader-Douglas; Cumara B O'Carroll; Maria I Aguilar; Patrick D Lyden; Gyanendra Kumar Journal: J Stroke Cerebrovasc Dis Date: 2018-03-20 Impact factor: 2.136
Authors: Kerry L Ivey; Jonathan M Hodgson; Kevin D Croft; Joshua R Lewis; Richard L Prince Journal: Am J Clin Nutr Date: 2015-04-01 Impact factor: 7.045
Authors: Wai Mun Loke; Jonathan M Hodgson; Julie M Proudfoot; Allan J McKinley; Ian B Puddey; Kevin D Croft Journal: Am J Clin Nutr Date: 2008-10 Impact factor: 7.045
Authors: Shweta Kaushik; Jie Jin Wang; Tien Y Wong; Victoria Flood; Alan Barclay; Jennie Brand-Miller; Paul Mitchell Journal: Stroke Date: 2008-10-23 Impact factor: 7.914
Authors: Alun D Hughes; Emanuela Falaschetti; Nicholas Witt; Sumangali Wijetunge; Simon A McG Thom; Therese Tillin; Steve J Aldington; Nish Chaturvedi Journal: Stroke Date: 2016-10-11 Impact factor: 7.914