Babak Rezanezhad1, Rasmus Borgquist2, Ronnie Willenheimer3, Saad Elzanaty4. 1. Department of Internal Medicine, Lund University, Lund, Sweden. 2. Department of Arrhythmia, Lund University, Lund, Sweden. 3. Department of Translational Medicine, Skåne University Hospital, Lund University, Lund, Sweden. 4. Department of Heart Health Group, Malmö, Sweden.
Abstract
OBJECTIVE: To study the associations between serum testosterone and risk factors for atherosclerosis in 119 men from general population. METHODS: Systolic pressure, body mass index (BMI), testosterone, fasting glucose, glucose tolerance test, apolipoprotein A-1 (ApoA-1), apolipoprotein B (ApoB), and ApoB/ApoA-1 ratio were assessed. Subjects classified into hypogonadal (testosterone ≤ 12 nmol/l), and eugonadal men (testosterone > 12 nmol/l). RESULTS: BMI (28 vs. 26 kg/ m<sup>2</sup>, p = 0.01), systolic pressure (129 vs. 123 mmHg, p = 0.03), fasting glucose (5.9 vs. 5.5 mmol/l, p = 0.03), ApoB (1.1 vs. 1.0 g/l, p = 0.03), and ApoB/ApoA-1 ratio (0.8 vs. 0.7, p = 0.03) were higher in hypogonadal compared to eugonadal men, respectively. In adjusted multivariate regression analysis model, testosterone showed negative associations with BMI (β = -1.832, p = 0.030, 95% CI = -3.485--0.180), fasting glucose (β = -0.394, p = 0.011, 95% CI = -0.696--0.091), glucose tolerance test (β = -0.957, p = 0.045, 95% CI = -1.892--0.022), ApoB (β = -0.157, p = 0.017, 95% CI = -0.286--0.029), and ApoB/ApoA-1 ratio (β = -0.118, p = 0.046, 95% CI = -0.234--0.002). CONCLUSIONS: These results suggest an inverse association between testosterone levels and risk factors for atherosclerosis.
OBJECTIVE: To study the associations between serum testosterone and risk factors for atherosclerosis in 119 men from general population. METHODS: Systolic pressure, body mass index (BMI), testosterone, fasting glucose, glucose tolerance test, apolipoprotein A-1 (ApoA-1), apolipoprotein B (ApoB), and ApoB/ApoA-1 ratio were assessed. Subjects classified into hypogonadal (testosterone ≤ 12 nmol/l), and eugonadal men (testosterone > 12 nmol/l). RESULTS: BMI (28 vs. 26 kg/ m<sup>2</sup>, p = 0.01), systolic pressure (129 vs. 123 mmHg, p = 0.03), fasting glucose (5.9 vs. 5.5 mmol/l, p = 0.03), ApoB (1.1 vs. 1.0 g/l, p = 0.03), and ApoB/ApoA-1 ratio (0.8 vs. 0.7, p = 0.03) were higher in hypogonadal compared to eugonadal men, respectively. In adjusted multivariate regression analysis model, testosterone showed negative associations with BMI (β = -1.832, p = 0.030, 95% CI = -3.485--0.180), fasting glucose (β = -0.394, p = 0.011, 95% CI = -0.696--0.091), glucose tolerance test (β = -0.957, p = 0.045, 95% CI = -1.892--0.022), ApoB (β = -0.157, p = 0.017, 95% CI = -0.286--0.029), and ApoB/ApoA-1 ratio (β = -0.118, p = 0.046, 95% CI = -0.234--0.002). CONCLUSIONS: These results suggest an inverse association between testosterone levels and risk factors for atherosclerosis.
Authors: Nicolaas T Malan; Roland von Känel; Alta E Schutte; Hugo W Huisman; Rudolph Schutte; Wayne Smith; Carina M Mels; Ruan Kruger; Muriel Meiring; Johannes M van Rooyen; Leoné Malan Journal: Int J Cardiol Date: 2013-07-30 Impact factor: 4.164
Authors: David E Laaksonen; Leo Niskanen; Kari Punnonen; Kristiina Nyyssönen; Tomi-Pekka Tuomainen; Veli-Pekka Valkonen; Jukka T Salonen Journal: J Clin Endocrinol Metab Date: 2004-11-09 Impact factor: 5.958