| Literature DB >> 31768027 |
Masaki Imai1, Makoto Yamashita2, Yuko Sakai-Tagawa2, Kiyoko Iwatsuki-Horimoto2, Maki Kiso2, Jurika Murakami2, Atsuhiro Yasuhara2, Kosuke Takada2, Mutsumi Ito2, Noriko Nakajima3, Kenta Takahashi3, Tiago J S Lopes2,4, Jayeeta Dutta5, Zenab Khan5, Divya Kriti5, Harm van Bakel5, Akifumi Tokita6,7, Haruhisa Hagiwara7,8, Naomi Izumida7,9, Haruo Kuroki10, Tamon Nishino7,11, Noriyuki Wada7,12, Michiko Koga13, Eisuke Adachi14, Daisuke Jubishi2,15, Hideki Hasegawa3,16, Yoshihiro Kawaoka17,18,19.
Abstract
Here we report the isolation of the influenza A/H1N1 2009 pandemic (A/H1N1pdm) and A/H3N2 viruses carrying an I38T mutation in the polymerase acidic protein-a mutation that confers reduced susceptibility to baloxavir marboxil-from patients before and after treatment with baloxavir marboxil in Japan. These variants showed replicative abilities and pathogenicity that is similar to those of wild-type isolates in hamsters; they also transmitted efficiently between ferrets by respiratory droplets.Entities:
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Year: 2019 PMID： 31768027 DOI： 10.1038/s41564-019-0609-0
Source DB: PubMed Journal: Nat Microbiol ISSN： 2058-5276 Impact factor: 17.745