Literature DB >> 31767626

Therapeutic Potential of the miRNA-ATM Axis in the Management of Tumor Radioresistance.

Abdol-Hossein Rezaeian1, Hashem Khanbabaei2, George A Calin3.   

Abstract

The ataxia-telangiectasia mutated (ATM) protein kinase is widely known for its function as a chief mobilizer of the DNA damage response (DDR) upon DNA double-strand breaks. ATM orchestrates the DDR by modulating the expression of various miRNAs through several mechanisms. On the other hand, a set of miRNAs contribute to tight regulation of ATM by directly targeting the 3'-untranslated region of ATM mRNA. This review addresses the therapeutic application and molecular mechanisms that underlie the intricate interactions between miRNAs and ATM. It also describes therapeutic delivery of miRNAs in different environments such as hypoxic tumor microenvironments. ©2019 American Association for Cancer Research.

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Year:  2019        PMID： 31767626     DOI： 10.1158/0008-5472.CAN-19-1807

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  14 in total

1.  Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation.

Authors:  Jun Liu; Tianyu Jin; Lanxi Ran; Ze Zhao; Rui Zhu; Gangcai Xie; Xiaolin Bi
Journal:  Hereditas       Date:  2022-10-21       Impact factor: 2.595

2.  Editorial: MicroRNA Signatures in Plant Genome Stability and Genotoxic Stress.

Authors:  Anca Macovei; Ignacio Rubio-Somoza; Jorge Almiro Pinto Paiva; Susana Araújo; Mattia Donà
Journal:  Front Plant Sci       Date:  2021-04-22       Impact factor: 5.753

Review 3.  CSC Radioresistance: A Therapeutic Challenge to Improve Radiotherapy Effectiveness in Cancer.

Authors:  María Auxiliadora Olivares-Urbano; Carmen Griñán-Lisón; Juan Antonio Marchal; María Isabel Núñez
Journal:  Cells       Date:  2020-07-09       Impact factor: 6.600

Review 4.  TGF-β and WNT signaling pathways in cardiac fibrosis: non-coding RNAs come into focus.

Authors:  Fatemeh Yousefi; Zahra Shabaninejad; Sina Vakili; Maryam Derakhshan; Ahmad Movahedpour; Hamed Dabiri; Younes Ghasemi; Maryam Mahjoubin-Tehran; Azin Nikoozadeh; Amir Savardashtaki; Hamed Mirzaei; Michael R Hamblin
Journal:  Cell Commun Signal       Date:  2020-06-09       Impact factor: 5.712

5.  Elevated Levels of circRUNX1 in Colorectal Cancer Promote Cell Growth and Metastasis via miR-145-5p/IGF1 Signalling.

Authors:  Zhi-Lei Chen; Xiang-Nan Li; Chun-Xiang Ye; Hong-Yu Chen; Zhen-Jun Wang
Journal:  Onco Targets Ther       Date:  2020-05-12       Impact factor: 4.147

6.  Integrative data modeling from lung and lymphatic cancer predicts functional roles for miR-34a and miR-16 in cell fate regulation.

Authors:  Shantanu Gupta; Daner A Silveira; Florencia M Barbé-Tuana; José Carlos M Mombach
Journal:  Sci Rep       Date:  2020-02-13       Impact factor: 4.379

Review 7.  Jack of all trades? The versatility of RNA in DNA double-strand break repair.

Authors:  Ruth F Ketley; Monika Gullerova
Journal:  Essays Biochem       Date:  2020-10-26       Impact factor: 8.000

Review 8.  Non-Genomic Actions of Estrogens on the DNA Repair Pathways Are Associated With Chemotherapy Resistance in Breast Cancer.

Authors:  Javier E Jiménez-Salazar; Rebeca Damian-Ferrara; Marcela Arteaga; Nikola Batina; Pablo Damián-Matsumura
Journal:  Front Oncol       Date:  2021-03-19       Impact factor: 6.244

Review 9.  ATM: Main Features, Signaling Pathways, and Its Diverse Roles in DNA Damage Response, Tumor Suppression, and Cancer Development.

Authors:  Liem Minh Phan; Abdol-Hossein Rezaeian
Journal:  Genes (Basel)       Date:  2021-05-30       Impact factor: 4.096

Review 10.  microRNAs Shape Myeloid Cell-Mediated Resistance to Cancer Immunotherapy.

Authors:  Elena Daveri; Elisabetta Vergani; Eriomina Shahaj; Laura Bergamaschi; Stefano La Magra; Michela Dosi; Chiara Castelli; Monica Rodolfo; Licia Rivoltini; Viviana Vallacchi; Veronica Huber
Journal:  Front Immunol       Date:  2020-07-22       Impact factor: 7.561
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